Intracranial, Extradural, Hemangiopericytoma in a Neonate

Abstract

Intracranial infantile hemangiopericytoma (HPC) is a rare, sparsely documented neoplasm with a relatively favorable prognosis than its adult counterpart. We describe a neonatal extradural, intracranial, infantile HPC managed with near-total excision.

Keywords: Extradural; hemangiopericytoma; intracranial; neonate; tumor; vascular.

Figure 1

Clinical photograph (a) of the protuberant temporal mass distorting the left palpebral fissure. Contrast-enhanced computed tomography axial view (b) and coronal reformatted image (c) showing the large, heterogeneously enhancing calvarial mass. Postoperative appearance (d) at 6-month follow-up. Contrast-enhanced computed tomography axial view (e) and coronal reformatted image (f) showing enhancing residual extracranial component (black arrow) and postoperative cystic cavity (star) in the left temporal region and infratemporal fossa

Figure 2

(a) Microscopy showed a cellular tumor in diffuse sheet with interspersed staghorn-shaped blood vessel (H and E, ×100) (b) The individual cells showed spindle-shaped nuclei, nuclear grooving, and bland chromatin (H and E, ×400) (c) Interspersed were erythroid colonies (black arrow) and megakaryocytes (blue arrow) (H and E, ×100) (d-f) Positive immunohistochemistry for CD99 (membranocytoplasmic, ×200, d), CD34 (membranous, ×200, e), and STAT6 (nuclear, ×400, f)