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Editorial
. 2020 Sep;8(17):1041.
doi: 10.21037/atm-2020-94.

Foxk1 regulates cancer progression

Daniel J Garry  1   2   3   4 , Geunho Maeng  1 , Mary G Garry  1   2
Affiliations
Editorial

Foxk1 regulates cancer progression

Daniel J Garry et al. Ann Transl Med. 2020 Sep.
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-2020-94). DJG and MGG report other from NorthStar Genomics, outside the submitted work. GM has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Foxk1 is an important regulator in stem cell and cancer cell populations. (A) Schematic highlighting the domains of the FOXK1 protein. The Sin3 interacting domain (SID) physically interacts with Sin3 and its associated complex. The Forkhead-Associated Domain (FHD) interacts with phosphothreonine proteins (such as SDS3) and is important in the regulation of cell cycle kinetics. The winged helix domain (WHD) binds to DNA and allows FOXK1 to function as a transcriptional regulator. The transcriptional activation domain (TAD) is located in the carboxy terminal region of the protein. (B) FOXK1 has been shown to have a number of permissive roles and repressive roles in stem cell and cancer cell populations.
See this image and copyright information in PMC

Comment on

References

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