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. 1987 Nov;129(2):302-12.

The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability

P E Parsons  1 , K Sugahara, G R Cott, R J Mason, P M Henson
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The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability

P E Parsons et al. Am J Pathol. 1987 Nov.

Abstract

The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability was examined. Although neutrophil migration was not associated with a change in epithelial permeability, prolonged neutrophil-epithelial contact following migration resulted in an increase in epithelial permeability. These results were not altered by catalase, a specific neutrophil elastase inhibitor, methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone or cyclohexamide. This suggests that neutrophil migration does not occur via an H2O2-induced reversible mechanism of junctional opening, which we describe herein.

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