Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2021 Jun;15(6):604-612.
doi: 10.1111/crj.13302. Epub 2021 Apr 19.

The association between outcomes and body mass index in patients with acute respiratory distress syndrome

Ziying Chen  1   2   3   4   5 , Xu Huang  2   3   4   5 , Haining Lu  6 , Wang Deng  7 , Linna Huang  2   3   4   5 , Dawei Wu  6 , Daoxin Wang  7 , Qingyuan Zhan  2   3   4   5
Affiliations
Multicenter Study

The association between outcomes and body mass index in patients with acute respiratory distress syndrome

Ziying Chen et al. Clin Respir J. 2021 Jun.

Abstract

Introduction: Limited information exists about the relationship between body mass index (BMI) and the outcome of acute respiratory distress syndrome (ARDS).

Objective: To evaluate the hospital mortality of patients with ARDS in relation to BMI.

Materials and methods: We conducted a retrospective, multicenter study including patients with ARDS. ARDS was defined according to the Berlin criteria. Body weight and height were obtained to calculate BMI. The primary outcome was in-hospital mortality. Secondary outcomes were intensive care unit (ICU) mortality, invasive positive pressure ventilation (IPPV) free days within 28 days and length of stays in the ICU and hospital.

Results: Among 523 patients, 28 (5%) were underweight (BMI <18.5 kg/m2 ), 299 (57%) were normal weight (BMI 18.5-24.9 kg/m2 ), 159 (30%) were overweight (BMI 25-29.9 kg/m2 ) and 37 (7%) were obese (BMI ≥30 kg/m2 ). Increasing BMI was associated with younger age (P = 0.017), hypertension (P = 0.003) and diabetes (P = 0.02). Compared with normal weight, being overweight and obese resulted in lower mortality regardless of whether in the hospital (P = 0.019) or ICU (P = 0.044). However, after risk adjustment, only obesity was associated with lower hospital mortality (OR 0.393, 95% CI 0.169-0.914, P = 0.030). With the increase of BMI, the in-hospital mortality and ICU mortality of ARDS dropped gradually (from 57.1% to 24.3%, P = 0.021, and from 53.6% to 24.3%, P = 0.035).

Conclusions: Obesity is associated with lower mortality in patients with ARDS. With the increase of BMI, the mortality of ARDS drops gradually.

Keywords: acute respiratory distress syndrome; adult; body mass index; obesity.

PubMed Disclaimer

Comment in

References

    1. Ranieri VM, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E Acute respiratory distress syndrome: the Berlin definition. JAMA. 2012;307(23):2526-2533.
    1. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012;122(8):2731-2740.
    1. Umbrello M, Fumagalli J, Pesenti A, et al. Pathophysiology and management of acute respiratory distress syndrome in obese patients. Semin Respir Crit Care Med. 2019;40(1):40-56.
    1. Bluher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288-298.
    1. Guo L, et al. Body mass index and cancer incidence:a prospective cohort study in northern China. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 2014;35(3):231-236.

Publication types

LinkOut - more resources