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. 2020 Nov 10;4(21):5389-5392.
doi: 10.1182/bloodadvances.2020003109.

B-lymphoblastic leukemia arising in a patient with chronic neutrophilic leukemia

Craig S Boddy  1 , Brent T Tan  2 , Joseph Aoki  3
Affiliations

B-lymphoblastic leukemia arising in a patient with chronic neutrophilic leukemia

Craig S Boddy et al. Blood Adv. .

Abstract

  1. We report the first identified case of chronic neutrophilic leukemia with transformation to B-lymphoblastic leukemia.

  2. Genetic alterations involving CSF3R, ASXL1, SRSF2, and RUNX1 contributed to the unusual progression and may drive B-cell leukemogenesis.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
CNL characterized by increased neutrophils and myeloid hyperplasia. The peripheral smear shows prominent neutrophilia (A; original magnification ×600; Wright's stain). The accompanying bone marrow aspirate illustrates myeloid hyperplasia with complete maturation (B; original magnification ×600; Wright's stain). The core biopsy is hypercellular and dominated by maturing myeloid elements (C; original magnification ×600) with no increase in CD34-positive blasts (D; original magnification ×600; hematoxylin and eosin stain).
Figure 2.
Figure 2.
B-LBL arising out of CNL. The peripheral smear demonstrates circulating blasts with single to multiple prominent nucleoli (A; original magnification ×600; Wright's stain). The bone marrow biopsy is markedly hypercellular with an increase in blasts (B; original magnification ×600; hematoxylin and eosin stain). By immunohistochemistry, the blasts coexpress CD79a (C; original magnification ×600) and CD34 (D; original magnification ×600).
See this image and copyright information in PMC

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