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Comment
. 2020 Nov 3;32(5):697-698.
doi: 10.1016/j.cmet.2020.10.014.

A Selective Sweep Conceals a MicroRNA with Broad Metabolic Effects

Iain Mathieson  1 , Struan F A Grant  2
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A Selective Sweep Conceals a MicroRNA with Broad Metabolic Effects

Iain Mathieson et al. Cell Metab. .
Free article

Abstract

The need for discovering new genes driving metabolic disease susceptibility is clear; even clearer is the need for their subsequent functional characterization. A new paper reports a role for miR-128-1 in metabolic control through a series of elegant mouse studies, and an intriguing hypothesis about its "thrifty" role in metabolism.

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  • A MicroRNA Linking Human Positive Selection and Metabolic Disorders.
    Wang L, Sinnott-Armstrong N, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, Tallapragada DSP, Strobel SM, Lee MJ, Tewhey R, Sabeti PC, Schaefer A, Petri A, Kauppinen S, Chung RT, Soukas A, Avruch J, Fried SK, Hauner H, Sadreyev RI, Shulman GI, Claussnitzer M, Näär AM. Wang L, et al. Cell. 2020 Oct 29;183(3):684-701.e14. doi: 10.1016/j.cell.2020.09.017. Epub 2020 Oct 14. Cell. 2020. PMID: 33058756 Free PMC article.

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