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Comment
. 2020 Nov 3;32(5):699-701.
doi: 10.1016/j.cmet.2020.10.016.

A Tug-of-War Over Methionine

Ke Xu  1 , Amy Shyu  2 , Ming O Li  3
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Free article
Comment

A Tug-of-War Over Methionine

Ke Xu et al. Cell Metab. .
Free article

Abstract

Nutrient acquisition and metabolism are integral components of cell growth, proliferation, and differentiation programs. In a recent study in Nature, Bian et al. (2020) revealed that cancer cells outcompete T cells for methionine uptake, resulting in diminished SAM production, attenuated H3K79 dimethylation, decreased STAT5 expression, and impaired T cell immunity to cancer.

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  • Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
    Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Pawłowska A, Xia H, Li J, Liao P, Yu J, Vatan L, Szeliga W, Wei S, Grove S, Liu JR, McLean K, Cieslik M, Chinnaiyan AM, Zgodziński W, Wallner G, Wertel I, Okła K, Kryczek I, Lyssiotis CA, Zou W. Bian Y, et al. Nature. 2020 Sep;585(7824):277-282. doi: 10.1038/s41586-020-2682-1. Epub 2020 Sep 2. Nature. 2020. PMID: 32879489 Free PMC article.

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