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. 2020 Nov 3;32(5):701-703.
doi: 10.1016/j.cmet.2020.10.003.

Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?

Giuseppe Gangarossa  1 , Serge Luquet  2
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Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?

Giuseppe Gangarossa et al. Cell Metab. .
Free article

Abstract

Neurons within the arcuate nucleus control energy balance and represent the functional substrates through which FGF1 deploys its anti-diabetic action. Alonge et al. (2020) now report that the integrity of arcuate perineuronal nets, an extracellular matrix component that enmeshes GABAergic neurons, is reversibly altered in diabetic rats and a key component for FGF1-mediated diabetic remission. These novel insights unravel how perineuronal nets dynamically contribute to the central control of glycemia.

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