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. 2020 Nov 2;9(11):3540.
doi: 10.3390/jcm9113540.

Surgical Management of Primary Hyperparathyroidism-Clinicopathologic Study of 1019 Cases from a Single Institution

Jacek Gawrychowski  1 , Grzegorz J Kowalski  1 , Grzegorz Buła  1 , Adam Bednarczyk  1 , Dominika Żądło  1 , Zbigniew Niedzielski  1 , Agata Gawrychowska  1 , Henryk Koziołek  1
Affiliations

Surgical Management of Primary Hyperparathyroidism-Clinicopathologic Study of 1019 Cases from a Single Institution

Jacek Gawrychowski et al. J Clin Med. .

Abstract

Background: Primary hyperparathyroidism (pHPT) is an endocrine disorder characterized by hypercalcemia and caused by the presence of disordered parathyroid glands. Parathyroidectomy is the only curative therapy for pHPT, but despite its high cure rate of 95-98%, there are still cases where hypercalcemia persists after this surgical procedure. The aim of this study was to present the results of a surgical treatment of patients due to primary hyperparathyroidism and failures related to the thoracic location of the affected glands.

Methods: We present a retrospective analysis of 1019 patients who underwent parathyroidectomy in our department in the period 1983-2018.

Results: Among the group of 1019 operated-on patients, treatment failed in 19 cases (1.9%). In 16 (84.2%) of them, the repeated operation was successful. In total, 1016 patients returned to normocalcemia.

Conclusions: Our results confirm that parathyreoidectomy is the treatment of choice for patients with primary hyperparathyroidism. The ectopic position of the parathyroid gland in the mediastinum is associated with an increased risk of surgical failure. Most parathyroid lesions in the mediastinum can be safely removed from the cervical access.

Keywords: ectopic mediastinal localization; parathyroidectomy; persistent hypercalcemia; primary hyperparathyroidism; remedial surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Number of operations in years 1983–2018.
Figure 2
Figure 2
Blood serum Ca2+ concentration before and after operation (*—p < 0.001).
Figure 3
Figure 3
Blood serum parathormone (PTH) concentration before and after operation (*—p < 0.001).
See this image and copyright information in PMC

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