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Review
. 2020 Nov 4;25(1):54.
doi: 10.1186/s40001-020-00454-x.

A meta-analysis of the impact of COVID-19 on liver dysfunction

Zeng-Hong Wu  1 , Dong-Liang Yang  2
Affiliations
Review

A meta-analysis of the impact of COVID-19 on liver dysfunction

Zeng-Hong Wu et al. Eur J Med Res. .

Abstract

Background: The novel coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to a worldwide pandemic. Except representative manifestation of pneumonia and acute respiratory symptoms, COVID-19 patients have also shown different levels of liver injury or liver dysfunction. The aim of our study was to explore the probable clinical severity and mortality of COVID-19 patients and their liver dysfunction.

Method: A combination of computer and manual retrieval was used to search in Medline through PubMed, EMBASE and Web of Science. Review Manager 5.3 software was used to examine the heterogeneity among the studies and to calculate the combined effect value (OR, 95CI). Subgroup analysis, sensitivity analysis, and publication bias test were also performed.

Results: We found a significant connection between liver dysfunction and mortality of COVID-19 patients with a pooled OR of 1.98 (95% CI 1.39-2.82; P = 0.0002). There was a significant association between AST and severity of COVID-19 with a pooled OR of 4.48 (95% CI 3.24-7.21; P < 0.001), and a pooled WMD of 3.35 (95% CI, 2.07 to 4.64; P < 0.001). In addition, there was a significant difference between TBIL and severity of COVID-19, with a pooled OR of 1.91 (95% CI 1.40-2.60; P < 0.001), and with a pooled WMD of 1.18 (95% CI, 0.78 to 1.58; P < 0.001).

Conclusion: The mortality and severity of COVID-19 patients are significantly associated with liver dysfunction. The non-survivors and severe COVID-19 patients have elevated serum AST levels than the survivors and non-severe COVID-19 patients. The results of this study form a basis for better clinical liver management of patients with COVID-19.

Keywords: COVID-19; Liver dysfunction; Liver injury; Meta-analysis; SARS-CoV-2.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Search strategy to identify articles on the relationship between liver dysfunction and COVID-19
Fig. 2
Fig. 2
The forest plot outcome for the connection between liver dysfunction and the mortality of patients with COVID-19. a Events between non-survivors and survivors. b ALT levels between non-survivors and survivors. c AST levels between non-survivors and survivors
Fig. 3
Fig. 3
The forest plot outcome for the connection between ALT and the severity of patients with COVID-19. a Events between non-severe and severe patients. b ALT levels between non-severe and severe patients
Fig. 4
Fig. 4
The forest plot outcome for the connection between AST and the severity of patients with COVID-19. a Events between non-severe and severe patients. b AST levels between non-severe and severe patients
Fig. 5
Fig. 5
The forest plot outcome for the connection between TBIL and the severity of patients with COVID-19. a Events between non-severe and severe patients. b TBIL levels between non-severe and severe patients
See this image and copyright information in PMC

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