Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov;61(11):1175-1180.

Comparison of the efficacy of 2 sedative protocols in pediatric dogs undergoing brainstem auditory-evoked response testing

Alejandra García de Carellán Mateo  1 , Elena Ríos Álvarez  1 , Carlos Ros  1
Affiliations

Comparison of the efficacy of 2 sedative protocols in pediatric dogs undergoing brainstem auditory-evoked response testing

Alejandra García de Carellán Mateo et al. Can Vet J. 2020 Nov.

Abstract
in English, French

This study compared the quality of sedation with dexmedetomidine or alfaxalone during brainstem auditory-evoked response (BAER) tests in 6- to 17-week-old dogs. This was a prospective, randomized clinical study involving 19 client-owned pediatric dogs of breeds with reported congenital deafness. Group A (GA) received alfaxalone, 2 mg/kg body weight (BW) (n = 9) and group D (GD) dexmedetomidine, 0.005 mg/kg BW, and postprocedure antagonism with atipamezole (n = 10) intramuscularly. Time from injection to sedation, duration of sedation, sedation scores, need for re-dosing, rectal temperature, pulse and respiratory rate were recorded at baseline, before and after the BAER test, and once recovered from sedation. Pulse rate was significantly lower in GD (P = 0.004) and the number of re-dosing was significantly higher in GA (P = 0.011). Both sedation protocols allowed good quality BAER test recordings in pediatric dogs. Sedation with dexmedetomidine required less re-dosing, whereas alfaxalone maintained more physiological pulse rates.

Comparaison de l’efficacité de 2 protocoles de sédation chez des chiens pédiatriques soumis à un test potentiel évoqué auditif. L’étude vise à comparer deux protocoles de sédation à base de la dexmédétomidine et de l’alfaxalone pour la réalisation de test de potentiels évoqués auditifs (PEA) chez les chiens âgés de 6 à 17 semaines. Il s’agit d’une étude clinique prospective, randomisée, incluant 19 chiens pédiatriques de propriétaire, appartenant à des races prédisposées à la surdité congénitale. Les groupe A (GA) a reçu de l’alfaxalone (2 mg/kg) (n = 9), ceux du groupe D (GD) de la dexmédétomidine (0,005 mg/kg) (n = 10), en intramusculaire. Ont été relevés : temps d’action, durée de sédation, scores de sédation, nombre de doses, température, pouls et fréquence respiratoire; au repos, avant et après le test PEA. Des différences statistiquement significatives ont été trouvées dans la fréquence du pouls, étant plus bas pour GD (P = 0,004) alors que le nombre de doses utilisées, étant supérieurs parmi GA (P = 0,011). Trois chiens avaient une surdité unilatérale. Les deux protocoles de sédation ont permis des enregistrements de bonne qualité. La sédation avec la dexmédétomidine a nécessité moins de redosage; cependant, l’alfaxalone induit un pouls cardiaque plus proche des valeurs physiologiques chez les jeunes chiens testés.(Traduit par les auteurs).

PubMed Disclaimer

References

    1. Strain GM. Congenital deafness and its recognition. Vet Clin North Am Small Anim Pract. 1999;29:895–907. - PubMed
    1. Strain GM. The genetics of deafness in domestic animals. Front Vet Sci. 2015;8:2–29. - PMC - PubMed
    1. Scheifele PM, Clark JG. Electrodiagnostic evaluation of auditory function in the dog. Vet Clin North Am Small Anim Pract. 2012;42:1241–1257. - PubMed
    1. Cuddon PA. Electrodiagnosis in Veterinary Neurology: Electromyography, Nerve Conduction Studies and Evoked Responses Loveland. Colorado: Veterinary Specialists of Northern Colorado; 2000. Brainstem Auditory Evoked Responses; pp. 124–153.
    1. Wilson WJ, Mills PC. Brainstem auditory-evoked response in dogs. Am J Vet Res. 2005;66:2177–2187. - PubMed

Publication types

LinkOut - more resources