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Review
. 2020 Aug;12(Suppl 1):S27-S36.
doi: 10.4103/jpbs.JPBS_121_20. Epub 2020 Aug 28.

Regenerative Capacity of Dental Pulp Stem Cells: A Systematic Review

Adlin S Rosaian  1 , Gururaj Narayana Rao  1 , Sunil P Mohan  2   3 , Mahalakshmi Vijayarajan  1 , Rebekkah C Prabhakaran  1 , Anand Sherwood  4
Affiliations
Review

Regenerative Capacity of Dental Pulp Stem Cells: A Systematic Review

Adlin S Rosaian et al. J Pharm Bioallied Sci. 2020 Aug.

Abstract

Objectives: The dental pulp contains undifferentiated mesenchymal cells, blood vessels and so on, which are responsible for routine functions of a tooth. The determination of stemness and regenerative properties using biomarkers and further application in routine practice may unravel its potential.

Materials and methods: Inclusion criteria-original research articles published in English, from 2000 to 2019, were collected both manually and by electronic search from databases of Cochrane, Medline, Embase, and PubMed. Exclusion criteria-articles other than English and review manuscripts were omitted. The shortlisted articles were reviewed for specific biomarkers, to assess the regenerative potential, stemness, and lineage of dental pulp stem cells.

Results: Of 512 articles, 64 were selected and reviewed to determine the mesenchymal, neurogenic, vasculogenic, hematopoietic, and stem cell potential. On the basis of the search analysis, a panel of markers was proposed.

Conclusion: The application of proposed markers, on a pulpectomized tissue derived from human teeth, may be helpful to determine the regenerative potential and the usefulness in regenerative medicine and tissue engineering.

Keywords: Biomarkers; dental pulp stem cells; regenerative medicine; stem cells; tissue engineering.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA diagram
See this image and copyright information in PMC

References

    1. Bakhtiar H, Mazidi SA, Mohammadi Asl S, Ellini MR, Moshiri A, Nekoofar MH, et al. The role of stem cell therapy in regeneration of dentine-pulp complex: a systematic review. Prog Biomater. 2018;7:249–68. - PMC - PubMed
    1. Yang X, Li L, Xiao L, Zhang D. Recycle the dental fairy’s package: overview of dental pulp stem cells. Stem Cell Res Ther. 2018;9:1–8. - PMC - PubMed
    1. Sloan AJ, Waddington RJ. Dental pulp stem cells: what, where, how? Int J Paediatr Dent. 2009;19:61–70. - PubMed
    1. Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E. Mesenchymal stem cells derived from dental pulp: A review. Stem Cells Int. 2016;2016:12. - PMC - PubMed
    1. Apel C, Forlenza OV, de Paula VJ, Talib LL, Denecke B, Eduardo CP, et al. The neuroprotective effect of dental pulp cells in models of Alzheimer’s and Parkinson’s disease. J Neural Transm. 2009;116:71–8. - PubMed