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. 2020 Oct 28:13:2309-2316.
doi: 10.2147/RMHP.S268235. eCollection 2020.

The Role of Obstetric Factors, miRNA-30d and miRNA-181a in Postpartum Women with Pelvic Organ Prolapse

Wenyu Lin #  1   2 , Liqing Lin #  3 , Binhua Dong  2   4 , Lihua Chen  1 , Huifang Lei  1   2 , Yuqin Gao  1   2 , Yaojia Chen  1   2 , Pengming Sun  1   2   4
Affiliations

The Role of Obstetric Factors, miRNA-30d and miRNA-181a in Postpartum Women with Pelvic Organ Prolapse

Wenyu Lin et al. Risk Manag Healthc Policy. .

Abstract

Background: The diagnosis of postpartum pelvic organ prolapse (POP) relies on symptoms combined with pelvic organ prolapse-quantification (POP-Q) and lacks serological indicators. The objective of this study was to assess serum elastin, type I collagen, miRNA-30d, and miRNA-181a in the early postpartum period to identify hematologic predictors of POP.

Material and methods: The study included 1013 42- to 60-day-postpartum women who had delivered at Quanzhou Women's and Children's Hospital from October 1, 2016, to October 31, 2017. This study was performed in accordance with the Declaration of Helsinki. The pregnancy and childbirth characteristics and pelvic floor function were evaluated. Forty cases with and without POP were matched, and serum elastin and type I collagen were determined by enzyme-linked immunosorbent assay (ELISA). Reverse-transcription polymerase chain reaction (RT-PCR) was used to detect miRNA-30d and miRNA-181a in 15 pairs.

Results: Of the 1013 women recruited, 699 (69.00%) were diagnosed with POP. The mean age was 29.00 years old, and the mean body mass index (BMI) was 22.6 kg/m2. In the univariate analysis, age ≥35 years (OR, 1.449; 95% CI, 0.965, 2.298), postpartum BMI ≥ 24 (OR, 4.402; 95% CI, 2.657, 6.148), neonatal weight ≥4 kg (OR, 4.832; 95% CI, 1.373, 17.290) and vaginal delivery (OR, 2.751; 95% CI, 1.855, 4.081) were risk factors for postpartum POP. There were no significant differences in the concentrations of serum elastin and type I collagen between the groups (P=0.52; P=0.26). There were significant differences in the concentrations of miRNA-30d and miRNA-181a between the groups (P=0.004; P=0.003).

Conclusion: miRNA-30d and miRNA-181a tended to be increased in women with POP and could be potential clinical predictors.

Keywords: elastin; miRNA-181a; miRNA-30d; pelvic organ prolapse; type I collagen.

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Conflict of interest statement

The authors declare that they have no conflicts of interest for this work.

Figures

Figure 1
Figure 1
Flow chart of the patients included.
Figure 2
Figure 2
Scatter diagram illustrating the difference of elastin and type I collagen level between women with and without Prolapse. (A) The difference of elastin concentrations (ng/mL) between women with and without Prolapse. (B) The difference of type I collagen concentrations (pg/mL) between women with and without Prolapse.#P>0.05.
Figure 3
Figure 3
Box-plot illustrating the difference of miRNA-30d and miRNA-181a level between women with and without Prolapse. (A) The difference of miRNA-30d (pg/mL) between women with and without Prolapse. (B) The difference of miRNA-181a concentrations (pg/mL) between women with and without Prolapse. *P<0.05.
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