Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Oct 13:2020:8876265.
doi: 10.1155/2020/8876265. eCollection 2020.

Epigenetic Regulation of Dental Pulp Stem Cell Fate

Dan Zhou  1 , Lu Gan  1 , Yiran Peng  1 , Yachuan Zhou  2 , Xin Zhou  1 , Mian Wan  2 , Yi Fan  2 , Xin Xu  2 , Xuedong Zhou  2 , Liwei Zheng  1 , Wei Du  2
Affiliations
Review

Epigenetic Regulation of Dental Pulp Stem Cell Fate

Dan Zhou et al. Stem Cells Int. .

Abstract

Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
The multilineage differentiation potential of DPSCs. DPSCs can differentiate into odontoblasts, osteoblasts, cementoblasts, neural cells, myoblasts, chondrocytes, endothelial cells, adipocytes, etc.
Figure 2
Figure 2
The modulation of DNA methylation and histone modifications during the odontogenic and osteogenic differentiation in DPSCs.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wu C., Morris J. R. Genes, genetics, and epigenetics: a correspondence. Science. 2001;293(5532):1103–1105. doi: 10.1126/science.293.5532.1103. - DOI - PubMed
    1. Williams S. C. P. Epigenetics. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(9):p. 3209. doi: 10.1073/pnas.1302488110. - DOI - PMC - PubMed
    1. Atlasi Y., Stunnenberg H. G. The interplay of epigenetic marks during stem cell differentiation and development. Nature Reviews Genetics. 2017;18(11):643–658. doi: 10.1038/nrg.2017.57. - DOI - PubMed
    1. Toh T. B., Lim J. J., Chow E. K. Epigenetics in cancer stem cells. Molecular Cancer. 2017;16(1):p. 29. doi: 10.1186/s12943-017-0596-9. - DOI - PMC - PubMed
    1. Mortada I., Mortada R. Epigenetic changes in mesenchymal stem cells differentiation. European Journal of Medical Genetics. 2018;61(2):114–118. doi: 10.1016/j.ejmg.2017.10.015. - DOI - PubMed

LinkOut - more resources