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. 2020 Dec;20(6):214.
doi: 10.3892/etm.2020.9344. Epub 2020 Oct 15.

Endurance of erythrocyte series in chemotherapy

Sorin Săftescu  1 , Dorel Popovici  1 , Cristina Oprean  1 , Alina Negru  2 , Adina Croitoru  3 , Mihail Zemba  4 , Ionela Yasar  4 , Maria Preda  5 , Șerban Negru  1
Affiliations

Endurance of erythrocyte series in chemotherapy

Sorin Săftescu et al. Exp Ther Med. 2020 Dec.

Abstract

Hematopoietic bone marrow toxicity is most often the limiting factor for chemotherapy doses. Increasing the intensity of chemotherapy doses (higher doses or more frequent administration) would improve antitumor effects, but the hematological toxicity does not allow these dose increases. This study evaluated the impact of chemotherapies on the parameters belonging to the red blood cell series in the hemogram and aimed to identify some particular evolution profiles. We selected 855 evaluations performed before the administration of chemotherapy belonging to the treatments initiated during the period December 2018-February 2020, containing 5-fluorouracil, cisplatin, docetaxel, epirubicin or pemetrexed. The data of the 644 evaluations related to the cycles 1-4 of chemotherapy were subject to this processing. The average relative loss of hemoglobin is -11% after the first three cycles of treatment, with statistically significant differences in hemoglobin levels in favor of men. There are risk factors associated with higher average losses, such as age <50 years or >65 years (statistically significant), body mass index (BMI) >25, cisplatin treatment (insufficient number of cases to reach statistical significance).

Keywords: bone marrow; cancer; chemotherapy; erythrocytes; haemoglobin.

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Figures

Figure 1
Figure 1
The evolution of the mean value of hemoglobinemia under chemotherapy.
Figure 2
Figure 2
The evolution of the average hemoglobin value by age groups.
Figure 3
Figure 3
The evolution of the average hemoglobin value according to different chemotherapies.
Figure 4
Figure 4
The evolution of the average hemoglobin value according to the height of the patients.
Figure 5
Figure 5
The evolution of the average hemoglobin value according to the level of creatinine.
Figure 6
Figure 6
The evolution of the average value of the mean corpuscular volume (MCV, fL) by age group.
Figure 7
Figure 7
The evolution of the average value of mean corpuscular volume (MCV, fL) according to the type of cytostatic.
Figure 8
Figure 8
The evolution of the average value of the mean corpuscular volume (MCV, fL) by body mass index (BMI, kg/m2).
See this image and copyright information in PMC

References

    1. Eaves CJ and Eaves AC: Anatomy and physiology of hematopoiesis. In: Childhood Leukemias. 2nd edition. Pui CH (ed). Cambridge University Press, Cambridge, pp69-105, 2006.
    1. Goodman SR, Kurdia A, Ammann L, Kakhniashvili D, Daescu O. The human red blood cell proteome and interactome. Exp Biol Med (Maywood) 2007;232:1391–1408. doi: 10.3181/0706-MR-156. - DOI - PubMed
    1. Koury MJ: Erythroferrone: A missing link in iron regulation. The Hematologist. American Society of Hematology 12, 2015.
    1. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46:678–684. doi: 10.1038/ng.2996. - DOI - PMC - PubMed
    1. Wan J, Ristenpart WD, Stone HA. Dynamics of shear-induced ATP release from red blood cells. Proc Natl Acad Sci USA. 2008;105:16432–16437. doi: 10.1073/pnas.0805779105. - DOI - PMC - PubMed

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