Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 27;4(3):168-177.
doi: 10.1002/ped4.12216. eCollection 2020 Sep.

Upfront consolidation treatment with 131I-mIbG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma

Jianhua Feng  1   2 , Frankie Wt Cheng  3 , Alex Wk Leung  1 , Vincent Lee  3 , Eva Wm Yeung  4 , Hoi Ching Lam  4 , Jeanny Cheung  3 , Grace Ks Lam  3 , Terry Tw Chow  3 , Carol Ls Yan  3 , Chi Kong Li  1   3
Affiliations

Upfront consolidation treatment with 131I-mIbG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma

Jianhua Feng et al. Pediatr Investig. .

Abstract

Importance: 131I-metaiodobenzylguanidine (131I-mIBG) has a significant targeted antitumor effect for neuroblastoma. However, currently there is a paucity of data for the use of 131I-mIBG as a "front-line" therapeutic agent in those patients with newly diagnosed high-risk neuroblastoma as part of the conditioning regimen for myeloablative chemotherapy (MAC).

Objective: To evaluate the feasibility of upfront consolidation treatment with 131I-mIBG plus MAC and hematopoietic stem cell transplantation (HSCT) in high-risk neuroblastoma patients.

Methods: A retrospective, single-center study was conducted from 2003-2019 on newly diagnosed high-risk neuroblastoma patients without progressive disease (PD) after the completion of induction therapy. They received 131I-mIBG infusion and MAC followed by HSCT.

Results: A total of 24 high-risk neuroblastoma patients were enrolled with a median age of 3.0 years at diagnosis. After receiving this sequential consolidation treatment, 3 of 13 patients who were in partial response (PR) before 131I-mIBG treatment achieved either complete response (CR) (n = 1) or very good partial response (VGPR) (n = 2) after HSCT. With a median follow-up duration of 13.0 months after 131I-mIBG therapy, the 5-year event-free survival and overall survival rates estimated were 29% and 38% for the entire cohort, and 53% and 67% for the patients who were in CR/VGPR at the time of 131I-mIBG treatment.

Interpretation: Upfront consolidation treatment with 131I-mIBG plus MAC and HSCT is feasible and tolerable in high-risk neuroblastoma patients, however the survival benefit of this 131I-mIBG regimen is only observed in the patients who were in CR/VGPR at the time of 131I-mIBG treatment.

Keywords: 131I‐mIBG; Neuroblastoma; Transplantation.

PubMed Disclaimer

Conflict of interest statement

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

Figures

FIGURE 1
FIGURE 1
Kaplan–Meier curves for event‐free survival (A) and overall survival (B) for the whole cohort, with 5‐year event‐free survival of 29% ± 11%, and 5‐year overall survival of 38% ± 12%. MIBG, metaiodobenzylguanidine.
FIGURE 2
FIGURE 2
Kaplan–Meier curves for event‐free survival (A) and overall survival (B) for 24 high‐risk neuroblastoma patients according to the disease status at the time of MIBG therapy. MIBG, metaiodobenzylguanidine; CR, complete response; VGPR, very good partial response; PR, partial response; MR, minor response.
See this image and copyright information in PMC

References

    1. Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet. 2007;369:2106–2120. - PubMed
    1. Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, Haas‐Kogan D, et al. Long‐term results for children with high‐risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13‐cis‐retinoic acid: A children’s oncology group study. J Clin Oncol. 2009;27:1007–1013. - PMC - PubMed
    1. Ladenstein R, Philip T, Lasset C, Hartmann O, Garaventa A, Pinkerton R, et al. Multivariate analysis of risk factors in stage 4 neuroblastoma patients over the age of one year treated with megatherapy and stem‐cell transplantation: A report from the European Bone Marrow Transplantation Solid Tumor Registry. J Clin Oncol. 1998;16:953–965. - PubMed
    1. Kreissman SG, Seeger RC, Matthay KK, London WB, Sposto R, Grupp SA, et al. Purged versus non‐purged peripheral blood stem‐cell transplantation for high‐risk neuroblastoma (COG A3973): A randomised phase 3 trial. Lancet Oncol. 2013;14:999–1008. - PMC - PubMed
    1. Liu K, Naranjo A, Zhang F, Dubois S, Braunstein S, Voss S, et al. Role of radiotherapy dose‐escalation for high‐risk neuroblastoma with post‐surgical primary site gross residual disease: A report from the COG ANBL0532 Study. Int J Radiat Oncol * Biol * Phys. 2019;105:S3.