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Comment
. 2020 Nov 5;136(19):2097-2099.
doi: 10.1182/blood.2020008316.

Implicating ILK in inflammation

Edward F Plow  1 , Daniel I Simon  2
Affiliations
Comment

Implicating ILK in inflammation

Edward F Plow et al. Blood. .

Abstract

In this issue of Blood, Margraf et al selectively delete integrin linked kinase (ILK) in myeloid cells of mice to show that this integrin-binding protein suppresses chemokine-induced neutrophil extravasation and ischemia-induced reperfusion injury.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
A new ILK-dependent pathway of LFA-1 activation on neutrophils. ILK facilitates recruitment of PCK-α to the cell membrane where it supports phosphorylation of a specific residue in kindlin-3. This modification enhances the capacity of kindlin-3 to cooperate with talin-1 to activate integrin LFA-1 and its recognition of ICAM-1. Illustration by Katarzyna Bialkowska.
See this image and copyright information in PMC

Comment on

References

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