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Comment
. 2021 Feb 15;203(4):526-527.
doi: 10.1164/rccm.202010-3873LE.

Alteration of the Renin-Angiotensin-Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3

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Comment

Alteration of the Renin-Angiotensin-Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3

Adrien Picod et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
An alternative renin–angiotensin–aldosterone system–disturbance hypothesis. Adapted from Reference . ACE = angiotensin-converting enzyme; DPP3 = dipeptidyl peptidase 3. Green arrows: increased concentration. Red arrows: decreased concentration. Red X: insufficient activity.

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References

    1. Bellomo R, Forni LG, Busse LW, McCurdy MT, Ham KR, Boldt DW, et al. Renin and survival in patients given angiotensin II for catecholamine-resistant vasodilatory shock: a clinical trial. Am J Respir Crit Care Med. 2020;202:1253–1261. - PMC - PubMed
    1. Bellomo R, Wunderink RG, Szerlip H, English SW, Busse LW, Deane AM, et al. Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock. Crit Care. 2020;24:43. - PMC - PubMed
    1. Rehfeld L, Funk E, Jha S, Macheroux P, Melander O, Bergmann A. Novel methods for the quantification of dipeptidyl peptidase 3 (DPP3) concentration and activity in human blood samples. J Appl Lab Med. 2019;3:943–953. - PubMed
    1. Prajapati SC, Chauhan SS. Dipeptidyl peptidase III: a multifaceted oligopeptide N-end cutter. FEBS J. 2011;278:3256–3276. - PubMed
    1. Deniau B, Rehfeld L, Santos K, Dienelt A, Azibani F, Sadoune M, et al. Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics. Eur J Heart Fail. 2020;22:290–299. - PubMed