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. 2020 Oct 29:13:563-570.
doi: 10.2147/PGPM.S275341. eCollection 2020.

Susceptibility of PON1/ PON2 Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population

Yuqin Pan #  1 , Bangshun He #  1 , Huiling Sun  1 , Tao Xu  1 , Bei Pan  1 , Shukui Wang  1 , Yanping Mei  2
Affiliations

Susceptibility of PON1/ PON2 Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population

Yuqin Pan et al. Pharmgenomics Pers Med. .

Abstract

Background: Paraoxonases (PONs) are a family of orphan enzymes with multiple functions, including anti-inflammatory, antioxidative, antiatherogenic activities. Studies have suggested that genetic variations in PON1 and PON2 are associated with ischemic stroke (IS) risk; however, the conclusion remains unclear in the Chinese population.

Methods: To investigate the susceptibility of genetic variations in PON1 and PON2 to risk of IS and its subtypes, this case-control study was carried out on a Chinese population comprising 300 IS patients and 300 healthy controls. Genotypes of six genetic variations in PON1 and PON2 were identified with an improved multiplex ligase detection-reaction technique.

Results: PON1 rs662 was associated with increased risk of IS (CT vs. TT - ORadjusted 1.79, 95% CI 1.08-2.97; p=0.025). Stratified analysis for patients by sex revealed that the significant association of PON1 rs662 with IS risk was maintained in the male cohort (CT vs. TT - ORadjusted 2.59, 95% CI 1.29-5.21 [p=0.009]; CT/CC vs. TT - ORadjusted 2.03, 95% CI 1.05-3.93 [p=0.036]), but not in the female cohort. Analysis according to IS subtype revealed that PON1 rs662 genetic variation was an increased risk in the subcohort of patients with large-artery atherosclerosis (CT/CC vs. TT - ORadjusted 2.31, 95% CI 1.09-4.91; p=0.029), but not in patients with other types of IS.

Conclusion: This study suggested that PON1 rs662 presented a potential risk of IS, especially for males, and this association was more obvious for large-artery atherosclerosis.

Keywords: PON1; PON2; genetic variation; ischemic stroke.

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Conflict of interest statement

The authors report no conflicts of interest for this work.

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