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Editorial
. 2021 Mar 21;117(4):983-984.
doi: 10.1093/cvr/cvaa246.

Two sides of the same coin: new insights into mechanisms of ventricular fibrillation

Vassilios J Bezzerides  1 , William T Pu  1   2
Affiliations
Editorial

Two sides of the same coin: new insights into mechanisms of ventricular fibrillation

Vassilios J Bezzerides et al. Cardiovasc Res. .
No abstract available

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Figures

Figure 1
Figure 1
VF organization is determined by gap junction coupling and fibrosis pattern. Organization of fibrillatory activity, spanning the spectrum of mechanisms from multiple wavelets (left) to a solitary mother-rotor (right), is determined by gap junction coupling and fibrosis pattern. Impaired gap junction coupling or a compact fibrosis pattern, such as observed after focal myocardial infarction, promoted disorganized VF, whereas enhanced gap junction coupling or patchy fibrosis caused by ischaemia-reperfusion injury was associated with a more organized VF pattern. Diffuse fibrosis from chronic pressure overload correlated with an intermediate phenotype.
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