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Review
. 2021 Jan;38(1):101-123.
doi: 10.1007/s10815-020-01987-0. Epub 2020 Nov 6.

Thoughts on the popularity of ICSI

Mounia Haddad  1 , Joshua Stewart  1 , Philip Xie  1 , Stephanie Cheung  1 , Aysha Trout  1 , Derek Keating  1 , Alessandra Parrella  1 , Sherina Lawrence  1 , Zev Rosenwaks  1 , Gianpiero D Palermo  2
Affiliations
Review

Thoughts on the popularity of ICSI

Mounia Haddad et al. J Assist Reprod Genet. 2021 Jan.

Abstract

Purpose: Intracytoplasmic sperm injection (ICSI) is the most widely utilized assisted reproductive technique (ART) worldwide. In this feature, we review the early assisted fertilization attempts that eventually led to the development of ICSI, and discuss its current utilization in cases of male and non-male factor infertility.

Methods: We researched the literature related to the development, indications, and current use of ICSI, such as sperm structural abnormalities, male genetic indications, surgically retrieved sperm, high sperm chromatin fragmentation, oocyte dysmorphism, and preimplantation genetic testing (PGT). We also describe the potential future applications of ICSI.

Results: This review summarizes the early micromanipulation techniques that led to the inception of ICSI. We also explore its current indications, including non-male factor infertility, where its use is more controversial. Finally, we consider the benefits of future advancements in reproductive biology that may incorporate ICSI, such as in vitro spermatogenesis, neogametogenesis, and heritable genome editing.

Conclusion: The versatility, consistency, and reliability of ICSI have made it the most prevalently utilized ART procedure worldwide.

Keywords: ART; Application of ICSI; Development of ICSI; History of ICSI; ICSI; IVF; Infertility; Popularity of ICSI; Versatility of ICSI.

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Figures

Fig. 1
Fig. 1
Indications of ICSI
Fig. 2
Fig. 2
Intracytoplasmic sperm injection (ICSI) procedure. (a) The injection (right) and holding (left) pipettes are placed into micromanipulation tool holders on an inverted microscope and positioned using hydraulic joysticks. The ICSI dish is placed on the microscope stage. (b) The injecting pipette enters from the 3 o’clock portion of the oocyte and deposits the spermatozoon at the 9 o’clock portion of the ooplasm
Fig. 3
Fig. 3
According to the most recent ICMART report, ICSI utilization was 66.5% worldwide in 2011 [1]. At Weill Cornell, our ICSI utilization has steadily increased from 1993 to 2019, with ICSI now utilized in over 95% of ART cycles done at the center
See this image and copyright information in PMC

References

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