Evidence of systemic endothelial injury and microthrombosis in hospitalized COVID-19 patients at different stages of the disease

Affiliations

¹ St. David's Medical Center, Austin, USA.
² Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Policlinico Universitario Umberto I, Sapienza University of Rome, Viale del Policlinico, 155- 00161, Rome, Italy. michele.magnocavallo@uniroma1.it.
³ Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Policlinico Universitario Umberto I, Sapienza University of Rome, Viale del Policlinico, 155- 00161, Rome, Italy.
⁴ Montefiore Medical Center, Bronx, NY, USA.
⁵ Azienda Ospedaliera-Universitaria Luigi Sacco, Milan, Italy.

^# Contributed equally.

Domenico G Della Rocca et al. J Thromb Thrombolysis. 2021 Apr.

. 2021 Apr;51(3):571-576.

doi: 10.1007/s11239-020-02330-1. Epub 2020 Nov 6.

¹ St. David's Medical Center, Austin, USA.
² Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Policlinico Universitario Umberto I, Sapienza University of Rome, Viale del Policlinico, 155- 00161, Rome, Italy. michele.magnocavallo@uniroma1.it.
³ Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Policlinico Universitario Umberto I, Sapienza University of Rome, Viale del Policlinico, 155- 00161, Rome, Italy.
⁴ Montefiore Medical Center, Bronx, NY, USA.
⁵ Azienda Ospedaliera-Universitaria Luigi Sacco, Milan, Italy.

^# Contributed equally.

No abstract available

Conflict of interest statement

All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

1. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020 doi: 10.1056/NEJMoa2015432. - DOI - PMC - PubMed
1. Schaller T, Hirschbühl K, Burkhardt K, Braun G, Trepel M, Märkl B, et al. Postmortem Examination of Patients With COVID-19. JAMA. 2020 doi: 10.1001/jama.2020.8907. - DOI - PMC - PubMed
1. Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. The Lancet. 2020;395:1417–1418. doi: 10.1016/S0140-6736(20)30937-5. - DOI - PMC - PubMed
1. Della Rocca DG, Pepine CJ. Some thoughts on the continuing dilemma of angina pectoris. Eur Heart J. 2014;35(21):1361–1364. doi: 10.1093/eurheartj/ehs225. - DOI - PubMed
1. Lowenstein CJ, Solomon SD. Severe COVID-19 is a Microvascular Disease. Circulation. 2020 doi: 10.1161/CIRCULATIONAHA.120.050354. - DOI - PMC - PubMed