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. 2020 Nov:6:1712-1720.
doi: 10.1200/GO.20.00368.

Incidence, Mortality, and Survival Trends of Primary CNS Tumors in Cali, Colombia, From 1962 to 2019

Ivy Riano  1 , Pablo Bravo  2 , Luis Eduardo Bravo  2 , Luz Stella Garcia  2 , Paola Collazos  2 , Edwin Carrascal  2
Affiliations

Incidence, Mortality, and Survival Trends of Primary CNS Tumors in Cali, Colombia, From 1962 to 2019

Ivy Riano et al. JCO Glob Oncol. 2020 Nov.

Abstract

Purpose: Global studies have shown varying trends of CNS tumors within geographic regions. In Colombia, the epidemiologic characteristics of CNS neoplasms are not well elucidated. We aimed to provide a summary of the descriptive epidemiology of primary CNS tumors among the urban population of Cali, Colombia.

Methods: We conducted a time-trend study from 1962 to 2019 using the Population-Based Cali Cancer Registry. The age-standardized rates per 100,000 person-years were obtained by direct method using the world standard population. Results were stratified by sex, age group at diagnosis, and histologic subtype. We used Joinpoint regression analysis to detect trends and obtain annual percentage change (APC) with 95% CIs. We estimated 5-year net survival using the Pohar-Perme method.

Results: During 1962 to 2016, 4,732 new cases of CNS tumors were reported. From 1985 to 2019, a total of 2,475 deaths from malignant CNS tumors were registered. A statistically significant increase in the trends of incidence (APC, 2.8; 95% CI, 2.1 to 3.5) and mortality (APC, 1.5; 95% CI, 1.1 to 2.0) rates was observed during the study. The most common malignant CNS tumor was glioblastoma (17.8% of all tumors), and the most frequent benign tumor was meningioma (17.2%). Malignancy was more common in males than in females. Unspecified malignant neoplasms represented 32% of all cases. The highest 5-year net survival was 31.4% during 2012 to 2016.

Conclusion: Our findings demonstrate an increasing burden of primary CNS tumors for the last 60 years, with a steady rate from the early 2010s. There was an improvement of 5-year net survival for the last decade. Males had higher mortality than did females. Additional efforts are needed to fully explore the geographic, environmental, and genetic contributors of CNS malignancies within the region.

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Conflict of interest statement

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/go/site/misc/authors.html.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

No potential conflicts of interest were reported.

Figures

FIG 1
FIG 1
Trends in incidence rates of primary brain and other CNS tumors presented by sex and behavior, 1962-2016. Data are from the Population-Based Cali Cancer Registry, Cali, Colombia. APC, annual percentage change; ASR, age-standardized rate per 100,000 person-years (world population [W]). The 10% of tumors with borderline behavior was excluded. (*) APC statistically different from zero (P < .05).
FIG 2
FIG 2
Trends in mortality rates of primary brain and other CNS tumors presented by sex, 1985-2019. Data are from the Population-Based Cali Cancer Registry, Cali, Colombia. APC, annual percentage change; ASR, age-standardized rate per 100,000 person-years (world population [W]). (*) APC statistically different from zero (P < .05).
FIG 3
FIG 3
Age-standardized 5-year net survival in adults (age 15 to 99 years) diagnosed with malignant brain tumors during 2000 to 2016, by calendar period of diagnosis. Data are from the Population-Based Cali Cancer Registry, Cali, Colombia.
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