Recent advances in vaccine and immunotherapy for COVID-19

doi:10.1080/21645515.2020.1825896

Review

. 2020 Dec 1;16(12):3011-3022.

doi: 10.1080/21645515.2020.1825896. Epub 2020 Nov 6.

Recent advances in vaccine and immunotherapy for COVID-19

Ali A Rabaan¹, Shamsah H Al-Ahmed², Ranjit Sah³, Jaffar A Al-Tawfiq^{4

5

6}, Ayman M Al-Qaaneh^{7

8}, Lamiaa H Al-Jamea⁹, Alexander Woodman⁹, Manaf Al-Qahtani^{10

11}, Shafiul Haque¹², Harapan Harapan^{13

14

15}, D Katterine Bonilla-Aldana^{16

17}, Pavan Kumar¹⁸, Kuldeep Dhama¹⁹, Alfonso J Rodriguez-Morales^{6

20}

Affiliations

¹ Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare , Dhahran, Saudi Arabia.
² Specialty Paediatric Medicine, Qatif Central Hospital , Qatif, Saudi Arabia.
³ Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine , Kathmandu, Nepal.
⁴ Specialty Internal Medicine, Johns Hopkins Aramco Healthcare , Dhahran, Saudi Arabia.
⁵ Department of Medicine, Indiana University School of Medicine , Indianapolis, IN, USA.
⁶ Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
⁷ Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University , Dammam, Saudi Arabia.
⁸ Clinical Pharmacy Services Division, Pharmacy Services Department, Johns Hopkins Aramco Healthcare , Dhahran, Saudi Arabia.
⁹ Clinical Laboratory Sciences, Prince Sultan Military College of Health Sciences , Dhahran, Saudi Arabia.
¹⁰ Department of Medicine, Royal Medical Services, Bahrain Defence Force Hospital , Manamah, Bahrain.
¹¹ Department of Medicine, Royal College of Surgeons in Ireland-Bahrain Medical University , Manamah, Bahrain.
¹² Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University , Jazan, Saudi Arabia.
¹³ Medical Research Unit, School of Medicine, Universitas Syiah Kuala , Banda Aceh, Indonesia.
¹⁴ Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala , Banda Aceh, Aceh, Indonesia.
¹⁵ Department of Microbiology, School of Medicine, Universitas Syiah Kuala , Banda Aceh, Aceh, Indonesia.
¹⁶ Semillero de Investigación en Zoonosis (SIZOO), Grupo de Investigación BIOECOS, Fundación Universitaria Autónoma de las Américas , Pereira, Risaralda, Colombia.
¹⁷ Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira , Pereira, Colombia.
¹⁸ College of Horticulture and Forestry, Rani Lakshmi Bai Central Agricultural University , Jhansi, India.
¹⁹ Division of Pathology, ICAR-Indian Veterinary Research Institute , Bareilly, Uttar Pradesh, India.
²⁰ Grupo De Investigacion Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Americas , Pereira, Colombia.

PMID: 33156739
PMCID: PMC7651183
DOI: 10.1080/21645515.2020.1825896

Review

Recent advances in vaccine and immunotherapy for COVID-19

Ali A Rabaan et al. Hum Vaccin Immunother. 2020.

. 2020 Dec 1;16(12):3011-3022.

doi: 10.1080/21645515.2020.1825896. Epub 2020 Nov 6.

Authors

Affiliations

¹ Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare , Dhahran, Saudi Arabia.
² Specialty Paediatric Medicine, Qatif Central Hospital , Qatif, Saudi Arabia.
³ Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine , Kathmandu, Nepal.
⁴ Specialty Internal Medicine, Johns Hopkins Aramco Healthcare , Dhahran, Saudi Arabia.
⁵ Department of Medicine, Indiana University School of Medicine , Indianapolis, IN, USA.
⁶ Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
⁷ Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University , Dammam, Saudi Arabia.
⁸ Clinical Pharmacy Services Division, Pharmacy Services Department, Johns Hopkins Aramco Healthcare , Dhahran, Saudi Arabia.
⁹ Clinical Laboratory Sciences, Prince Sultan Military College of Health Sciences , Dhahran, Saudi Arabia.
¹⁰ Department of Medicine, Royal Medical Services, Bahrain Defence Force Hospital , Manamah, Bahrain.
¹¹ Department of Medicine, Royal College of Surgeons in Ireland-Bahrain Medical University , Manamah, Bahrain.
¹² Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University , Jazan, Saudi Arabia.
¹³ Medical Research Unit, School of Medicine, Universitas Syiah Kuala , Banda Aceh, Indonesia.
¹⁴ Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala , Banda Aceh, Aceh, Indonesia.
¹⁵ Department of Microbiology, School of Medicine, Universitas Syiah Kuala , Banda Aceh, Aceh, Indonesia.
¹⁶ Semillero de Investigación en Zoonosis (SIZOO), Grupo de Investigación BIOECOS, Fundación Universitaria Autónoma de las Américas , Pereira, Risaralda, Colombia.
¹⁷ Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira , Pereira, Colombia.
¹⁸ College of Horticulture and Forestry, Rani Lakshmi Bai Central Agricultural University , Jhansi, India.
¹⁹ Division of Pathology, ICAR-Indian Veterinary Research Institute , Bareilly, Uttar Pradesh, India.
²⁰ Grupo De Investigacion Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Americas , Pereira, Colombia.

PMID: 33156739
PMCID: PMC7651183
DOI: 10.1080/21645515.2020.1825896

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 has resulted in millions of cases and hundreds of thousands of deaths. Beyond there being no available antiviral therapy, stimulating protective immunity by vaccines is the best option for managing future infections. Development of a vaccine for a novel virus is a challenging effort that may take several years to accomplish. This mini-review summarizes the immunopathological responses to SARS-CoV-2 infection and discusses advances in the development of vaccines and immunotherapeutics for COVID-19.

Keywords: COVID-19; SARS-CoV-2; immunotherapeutics; pandemic; vaccine.

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References

1. Leibowitz J. Coronaviruses: molecular and cellular biology. Emerg Infect Dis. 2008;14(4):693b–694. doi:10.3201/eid1404.080016. - DOI
1. Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020;104(3):246–51. doi:10.1016/j.jhin.2020.01.022. - DOI - PMC - PubMed
1. Accessed 2020 August 28. https://www.worldometers.info/world-population/
1. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Napoli RD. Features, evaluation and treatment coronavirus (COVID-19). - PubMed
1. Fauci AS, Lane HC, Redfield RR. Covid-19—navigating the uncharted. N Engl J Med. 2020;382:1268–69. (published online February 28.). doi:10.1056/NEJMe2002387. - DOI - PMC - PubMed

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[1] Leibowitz J. Coronaviruses: molecular and cellular biology. Emerg Infect Dis. 2008;14(4):693b–694. doi:10.3201/eid1404.080016. - DOI

[2] Leibowitz J. Coronaviruses: molecular and cellular biology. Emerg Infect Dis. 2008;14(4):693b–694. doi:10.3201/eid1404.080016. - DOI

[3] Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020;104(3):246–51. doi:10.1016/j.jhin.2020.01.022. - DOI - PMC - PubMed

[4] Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020;104(3):246–51. doi:10.1016/j.jhin.2020.01.022. - DOI - PMC - PubMed

[5] Accessed 2020 August 28. https://www.worldometers.info/world-population/

[6] Accessed 2020 August 28. https://www.worldometers.info/world-population/

[7] Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Napoli RD. Features, evaluation and treatment coronavirus (COVID-19). - PubMed

[8] Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Napoli RD. Features, evaluation and treatment coronavirus (COVID-19). - PubMed

[9] Fauci AS, Lane HC, Redfield RR. Covid-19—navigating the uncharted. N Engl J Med. 2020;382:1268–69. (published online February 28.). doi:10.1056/NEJMe2002387. - DOI - PMC - PubMed

[10] Fauci AS, Lane HC, Redfield RR. Covid-19—navigating the uncharted. N Engl J Med. 2020;382:1268–69. (published online February 28.). doi:10.1056/NEJMe2002387. - DOI - PMC - PubMed

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Recent advances in vaccine and immunotherapy for COVID-19

Affiliations

Recent advances in vaccine and immunotherapy for COVID-19

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