Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Nov 5;80(3):381-383.
doi: 10.1016/j.molcel.2020.10.002.

Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

Divakar S Mithal  1 , Navdeep S Chandel  2
Affiliations
Free article
Comment

Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

Divakar S Mithal et al. Mol Cell. .
Free article

Abstract

Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.

PubMed Disclaimer

Comment on

  • ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome.
    Licznerski P, Park HA, Rolyan H, Chen R, Mnatsakanyan N, Miranda P, Graham M, Wu J, Cruz-Reyes N, Mehta N, Sohail S, Salcedo J, Song E, Effman C, Effman S, Brandao L, Xu GN, Braker A, Gribkoff VK, Levy RJ, Jonas EA. Licznerski P, et al. Cell. 2020 Sep 3;182(5):1170-1185.e9. doi: 10.1016/j.cell.2020.07.008. Epub 2020 Aug 13. Cell. 2020. PMID: 32795412 Free PMC article.

Substances

LinkOut - more resources