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Comment
. 2020 Nov 5;27(5):693-695.
doi: 10.1016/j.stem.2020.10.007.

Targeting LSCs: Peeling Back the Curtain on the Metabolic Complexities of AML

Tian Y Zhang  1 , Ravindra Majeti  2
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Targeting LSCs: Peeling Back the Curtain on the Metabolic Complexities of AML

Tian Y Zhang et al. Cell Stem Cell. .
Free article

Abstract

Most patients with AML succumb to chemoresistant leukemia stem cells (LSCs), which persist and reinitiate disease years after clinical remission. In this issue of Cell Stem Cell, Jones et al. (2020) identify a therapeutically targetable mechanism of resistance to venetoclax in relapsed and refractory AML LSCs mediated by nicotinamide metabolism.

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Conflict of interest statement

Declaration of Interests R.M. serves on the Board of Directors of BeyondSpring Inc., is a member of the Scientific Advisory Boards for Kodikaz Therapeutic Solutions, Coherus Biosciences, and Zenshine Pharmaceuticals, and is an inventor on multiple patients related to CD47 cancer immunotherapy licensed to Gilead.

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