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Comment
. 2020 Nov 5;27(5):695-697.
doi: 10.1016/j.stem.2020.10.011.

A "Switch" in Time through Genes Aligned: Unraveling the Genomic Landscape of HSC Development

April C Apostol  1 , Diego A López  2 , Anna E Beaudin  3
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A "Switch" in Time through Genes Aligned: Unraveling the Genomic Landscape of HSC Development

April C Apostol et al. Cell Stem Cell. .
Free article

Abstract

Seeking to define the "switch" from fetal to adult hematopoiesis, Li et al. (2020) performed extensive genomic and epigenomic profiling of hematopoietic stem and progenitor cells across ontogeny (as explored in this issue of Cell Stem Cell). Gradual and stochastic changes in genomic and epigenomic regulation suggest the absence of any specific regulator.

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