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Comment
. 2020 Nov 5;27(5):699-701.
doi: 10.1016/j.stem.2020.10.010.

A Purpose in Liquidity: Perfusing 3D Open Scaffolds Improves "Mini-gut" Morphogenesis and Longevity

Christopher R Schlieve  1 , Tracy C Grikscheit  2
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A Purpose in Liquidity: Perfusing 3D Open Scaffolds Improves "Mini-gut" Morphogenesis and Longevity

Christopher R Schlieve et al. Cell Stem Cell. .
Free article

Abstract

Channeling morphogenic signaling gradients intrinsic to intestinal epithelial stem cells, Nikolaev et al. (2020) optimized a three-dimensional microchip perfusion system that augments growth, maturation, and longevity of tubular intestinal enteroids. Reported in Nature, this system may ultimately pave the way to study human intestinal development and pathophysiology, perhaps for therapeutic discovery.

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