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. 2021 Jan:114:154417.
doi: 10.1016/j.metabol.2020.154417. Epub 2020 Nov 4.

Do biomarkers of COVID-19 severity simply reflect a stress response in type 2 diabetes: Biomarker response to hypoglycemia

Abu Saleh Md Moin  1 , Ahmed Al-Qaissi  2 , Thozhukat Sathyapalan  3 , Stephen L Atkin  4 , Alexandra E Butler  5
Affiliations

Do biomarkers of COVID-19 severity simply reflect a stress response in type 2 diabetes: Biomarker response to hypoglycemia

Abu Saleh Md Moin et al. Metabolism. 2021 Jan.
No abstract available

Keywords: COVID-19; Cytokine; Hypoglycemia; SARS-CoV-2; Type 2 diabetes.

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Conflict of interest statement

Declaration of competing interest No authors have any conflict of interest or competing interests to declare.

Figures

Fig. 1
Fig. 1
Comparison of circulatory levels of cytokines reported as biomarkers of incipient severe COVID-19 disease in plasma before, during and after iatrogenic induction of hypoglycemia. Blood sampling was performed at baseline (BL), at hypoglycemia (0 min) and post-hypoglycemia (30 min, 1-h, 2-h, 4-h and 24-h) for controls (white circles) and for T2D (black squares). At baseline (BL), blood sugar (BS) was 7.5 ± 0.4 mM (for T2D) and 5.0 ± 0.1 mM (for control, C). At point of hypoglycemia, blood sugar (BS) was 2.0 ± 0.03 mM (for T2D) and 1.8 ± 0.05 mM (for controls). Proteomic (Somalogic) analysis of amyloid-related proteins was undertaken for Chemokine (C-C motif) ligand 17 [CCL17] (A), Chemokine (C-X-C motif) ligand 9 [CXCL9] (B), Interleukin 6 [IL-6] (C), Chemokine (C-X-C motif) ligand 10 [CXCL10] (D), Interferon lambda 1 [IFNλ1] (E). Statistics: (*, p < 0.05 or **, p < 0.01, control vs T2D); (^, p < 0.05, control baseline vs control hypoglycemia); (#, p < 0.05, control hypoglycemia vs control post-hypoglycemia timepoints); ($, p < 0.05, $$, p < 0.01, T2D hypoglycemia vs T2D post-hypoglycemia timepoints); (&, p < 0.05, T2D baseline vs T2D post-hypoglycemia timepoints); (^, p < 0.05, T2D hypoglycemia vs T2D post-hypoglycemia timepoints); (#%, p < 0.01, control baseline vs control post-hypoglycemia timepoints). RFU, relative fluorescent units.
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