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. 2020 Nov 6;99(45):e23088.
doi: 10.1097/MD.0000000000023088.

A study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia

Mohamed A Yassin  1 , Sadek A Nehmeh  2 , Abdulqadir J Nashwan  3 , Samah A Kohla  4 , Shehab F Mohamed  1 , Omar M Ismail  1 , Ahmad Al Sabbagh  4 , Firyal Ibrahim  4 , Dina S Soliman  4 , Lajos Szabados  5 , Hadi Fayad  6
Affiliations

A study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia

Mohamed A Yassin et al. Medicine (Baltimore). .

Abstract

The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden.This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017.

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Conflict of interest statement

The authors have no conflicts of interests to disclose.

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