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Comment
. 2020 Dec;41(12):1054-1056.
doi: 10.1016/j.it.2020.10.010. Epub 2020 Nov 3.

Lysozyme: A Double-Edged Sword in the Intestine

Mor Zigdon  1 , Shai Bel  2
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Lysozyme: A Double-Edged Sword in the Intestine

Mor Zigdon et al. Trends Immunol. 2020 Dec.

Abstract

Lysozyme-secreting Paneth cells are abnormally present in the distal colons of patients with inflammatory bowel disease (IBD), along with high amounts of lysozyme in feces. In a recent article in Immunity, Yu et al. show that lysozyme-mediated processing of luminal bacteria in the colon triggers a proinflammatory response and predisposes mice to experimental IBD.

Keywords: colitis; immune response; inflammatory bowel diseases; lysozyme; microbiota.

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