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. 2021 Jan;53(1):138-149.
doi: 10.1111/apt.16145. Epub 2020 Nov 7.

Fatigue in inflammatory bowel disease and its impact on daily activities

Philipp Schreiner  1 , Jean-Benoît Rossel  2 , Luc Biedermann  1 , Philipp O Valko  3 , Christian R Baumann  3 , Thomas Greuter  1 , Michael Scharl  1 , Stephan R Vavricka  1   4 , Valérie Pittet  2 , Pascal Juillerat  5 , Gerhard Rogler  1 , Roland von Känel  6 , Benjamin Misselwitz  1   5 ; Swiss IBD Cohort Study Group
Collaborators, Affiliations

Fatigue in inflammatory bowel disease and its impact on daily activities

Philipp Schreiner et al. Aliment Pharmacol Ther. 2021 Jan.

Abstract

Background: Fatigue is a common symptom of chronic inflammation, including inflammatory bowel disease (IBD), resulting in significant impairment in quality of life.

Aims: To identify the prevalence of fatigue in a large IBD cohort compared to the general population, address risk factors, and evaluate its impact on daily life.

Methods: We evaluated 1208 IBD patients from the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) and 414 healthy controls. Significant fatigue was defined as a visual analogue scale (VAS-F, range 0-10) score ≥ 4. Secondary endpoints were severity of fatigue and its impact on daily activities with the Fatigue Severity Scale (FSS), with a score ≥ 4 indicative of fatigue. Demographic, IBD-related and psychiatric symptoms were assessed with a multivariate analysis of variance (MANOVA) model optimised for prediction of VAS-F (primary outcome) and FSS scores.

Results: Overall, 672 IBD patients (55.6%) reported significant fatigue compared to 145 (35%) controls (OR 2.71; 95% CI 2.08-3.54; P < 0.001). In IBD, fatigue also significantly affected daily activities (FSS ≥ 4; 405 (33.5%) IBD patients vs 81 (19.6%) controls, P < 0.001). In the MANOVA model, fatigue levels were associated with female gender (coefficient 0.839; 0.556 - 1.123; P < 0.001), younger age at diagnosis (-0.031 per year; -0.042- -0.019; P < 0.001), shorter disease duration (-0.036 per year; -0.050- -0.022; P < 0.001), nocturnal diarrhoea (0.718; 0.295-1.141; P = 0.001), low educational level (P = 0.034) and symptoms of depression and anxiety.

Conclusions: Fatigue is both more frequent and more severe in patients with IBD than in the general population.

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References

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