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Review
. 2021 Jan;16(1):89-97.
doi: 10.1016/j.cpet.2020.09.011. Epub 2020 Nov 5.

Total-Body PET Imaging in Infectious Diseases

Timothy J Henrich  1 , Terry Jones  2 , Denis Beckford-Vera  3 , Patricia M Price  4 , Henry F VanBrocklin  3
Affiliations
Review

Total-Body PET Imaging in Infectious Diseases

Timothy J Henrich et al. PET Clin. 2021 Jan.

Abstract

Total-body PET enables high-sensitivity imaging with dramatically improved signal-to-noise ratio. These enhanced performance characteristics allow for decreased PET scanning times acquiring data "total-body wide" and can be leveraged to decrease the amount of radiotracer required, thereby permitting more frequent imaging or longer imaging periods during radiotracer decay. Novel approaches to PET imaging of infectious diseases are emerging, including those that directly visualize pathogens in vivo and characterize concomitant immune responses and inflammation. Efforts to develop these imaging approaches are hampered by challenges of traditional imaging platforms, which may be overcome by novel total-body PET strategies.

Keywords: COVID-19; Human immunodeficiency syndrome; Infectious diseases; T cells; Total-body PET.

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Conflict of interest statement

Conflict statement T.J. Henrich receives grant support from Gilead Sciences, Merck, and Bristol Myers Squibb. UC Davis has a revenue sharing agreement with United Imaging Healthcare.

Figures

Figure 1.
Figure 1.
[18F]Raltegravir PET imaging in a participant with HIV on suppressive ART. Maximum intensity projections acquired immediately and 60 minutes following intravenous injection demonstrate rapid elimination of tracer from tissues that may harbor persistent HIV (A). Axial PET-MR overlays of inguinal lymph nodes regions are shown in (B). Low tracer uptake was identified in inguinal lymph nodes highlighting the need for high sensitivity total-body PET imaging that will allows for dynamic temporal imaging of antiretroviral tissue distribution and kinetics.
Figure 2.
Figure 2.
Biodistribution: Whole-body images of a participant at various times after injection of 89Zr-IAB22M2C (CD8 T cell-specific minibody; 1.5-mg dose). All images show most intense activity within spleen, followed by marrow, liver, and kidneys. Reproduced from Pandit-Taskar et al..
See this image and copyright information in PMC

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