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Review
. 2020 Nov;33(6):366-371.
doi: 10.1055/s-0040-1714241. Epub 2020 Nov 2.

Nonoperative Management for T2 Low Rectal Cancer: A Western Approach

Laura Melina Fernandez  1   2 , Guilherme Pagin São Julião  1 , Bruna Borba Vailati  1 , Angelita Habr-Gama  1 , Rodrigo Oliva Perez  1
Affiliations
Review

Nonoperative Management for T2 Low Rectal Cancer: A Western Approach

Laura Melina Fernandez et al. Clin Colon Rectal Surg. 2020 Nov.

Abstract

The possibility of organ preservation in early rectal cancer has gained popularity during recent years. Patients with early tumor stage and low risk for local recurrence do not usually require neoadjuvant chemoradiation for oncological reasons. However, these patients may be considered for chemoradiation exclusively for the purpose of achieving a complete clinical response and avoid total mesorectal excision. In addition, cT2 tumors may be more likely to develop complete response to neoadjuvant therapy and may constitute ideal candidates for organ-preserving strategies. In the setting where the use of chemoradiation is exclusively used to avoid major surgery, one should consider maximizing tumor response. In this article, we will focus on the rationale, indications, and outcomes of patients with early rectal cancer being treated by neoadjuvant chemoradiation to achieve organ preservation by avoiding total mesorectal excision.

Keywords: early tumor; rectal cancer; watch and wait.

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Conflict of interest statement

Conflict of Interest None.

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