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Comment
. 2020 Oct 14:11:585922.
doi: 10.3389/fendo.2020.585922. eCollection 2020.

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Amin Ardestani  1   2 , Kathrin Maedler  1
Affiliations
Comment

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Amin Ardestani et al. Front Endocrinol (Lausanne). .
No abstract available

Keywords: COVID-19; SARS-CoV-2; beta-cell; cytokine storm; diabetes; inflammation.

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Figures

Figure 1
Figure 1
Lung alveolar cells, pancreatic α- and β-cells, hepatocytes, cardiomyocytes, and dopaminergic neurons are specifically permissive to SARS-CoV-2 virus infection. (A) SARS-CoV-2 enters cells through the ACE2 receptor and the effector protease TMPRSS2, both expressed on lung alveolar cells and on many other cells in the body, although viral load does not essentially correlate with their expression. Organs affected by the metabolic syndrome are specifically permissive to SARS-CoV-2 infection which is a potential reason for the metabolic deterioration and the more severe disease, seen in COVID-19 patients with obesity and diabetes. (B) The “cytokine storm”, i.e. the massive cytokine production by SARS-CoV-2 infected cells may lead to destruction of insulin producing β-cells in the pancreas, which are specifically vulnerable to inflammatory cell death cascades. Consequent activation of cytotoxic CD4+ and CD8+ T-cells and migration of macrophages may initiate auto-immunity and acute onset of diabetes after COVID-19. Anti-inflammatory therapies, which have been shown to protect β-cells from the vicious cycle of cytokines need to be evaluated for an add-on anti-viral therapy for COVID-19 patients with diabetes or at risk for T2D or T1D. Created using smart servier medical art under https://creativecommons.org/licenses/by/3.0/ .
See this image and copyright information in PMC

Comment on

  • A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
    Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S. Yang L, et al. Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7. doi: 10.1016/j.stem.2020.06.015. Epub 2020 Jun 19. Cell Stem Cell. 2020. PMID: 32579880 Free PMC article.

References

    1. Rubino F, Amiel SA, Zimmet P, Alberti G, Bornstein S, Eckel RH, et al. New-Onset Diabetes in Covid-19. N Engl J Med (2020) 383:789–90. 10.1056/NEJMc2018688 - DOI - PMC - PubMed
    1. Bornstein SR, Rubino F, Khunti K, Mingrone G, Hopkins D, Birkenfeld AL, et al. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol (2020) 8(6):546–50. 10.1016/S2213-8587(20)30223-0 - DOI - PMC - PubMed
    1. Zhu L, She ZG, Cheng X, Qin JJ, Zhang XJ, Cai J, et al. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab (2020) 31(6):1068–77 e3. 10.1016/j.cmet.2020.04.021 - DOI - PMC - PubMed
    1. Wang S, Ma P, Zhang S, Song S, Wang Z, Ma Y, et al. Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study. Diabetologia (2020) 63:2102–11. 10.1007/s00125-020-05209-1 - DOI - PMC - PubMed
    1. Chee YJ, Ng SJH, Yeoh E. Diabetic ketoacidosis precipitated by Covid-19 in a patient with newly diagnosed diabetes mellitus. Diabetes Res Clin Pract (2020) 164:108166. 10.1016/j.diabres.2020.108166 - DOI - PMC - PubMed