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Review
. 2020 Oct 24:2020:1627824.
doi: 10.1155/2020/1627824. eCollection 2020.

Cytomegalovirus and Epstein-Barr Infections: Prevalence and Impact on Patients with Hematological Diseases

Jean de Melo Silva  1 , Renato Pinheiro-Silva  1 , Anamika Dhyani  1 , Gemilson Soares Pontes  1   2
Affiliations
Review

Cytomegalovirus and Epstein-Barr Infections: Prevalence and Impact on Patients with Hematological Diseases

Jean de Melo Silva et al. Biomed Res Int. .

Abstract

Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are widely distributed throughout the world. EBV is linked to various hematological and autoimmune disorders whereas CMV might play important role in the progression of chronic hematological diseases, such as hemoglobinopathies, lymphomas, myelomas, hemophilia, and aplastic and sickle cell anemia. Both viruses produce a viral homolog of human interleukin-10 that can cause general suppression of immune response, increasing susceptibility to other infections. These viruses can remain latent in the host cells and be reactivated when the host immune system is compromised. Studies showing the impact of CMV and EBV infections on hematological disorders are scarce and unclear in the context of coinfection. This review intends to present the biology, prevalence, and impact of CMV and EBV infections in patients with hematological diseases.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Structural characteristics of CMV and EBV.
Figure 2
Figure 2
CMV and EBV life cycles. (a1, a2) Viral invasion. (b) Capsid transportation to the nucleus. (c) Expression of IE, DE, and L genes and start of genome replication. (d) Formation of the viral assembly complex (AC). (e) Release of the new infectious particles.
Figure 3
Figure 3
Clinical manifestations associated to CMV or EBV infections in patients with hematological diseases.
Figure 4
Figure 4
Hematological diseases associated to EBV/CMV infection.
See this image and copyright information in PMC

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References

    1. Cannon M. J., Schmid D. S., Hyde T. B. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Reviews in Medical Virology. 2010;20(4):202–213. doi: 10.1002/rmv.655. - DOI - PubMed
    1. de Oliveira J. L., Freitas R. T., Arcuri L. J., et al. O vírus Epstein-Barr e a mononucleose infecciosa. Revista Brasileira de Clínica Médica. 2012;10(6):535–543.
    1. Zhang Q., Gao Y., Peng Y., et al. Epidemiological survey of human cytomegalovirus antibody levels in children from Southeastern China. Virology Journal. 2014;11(1):1–6. - PMC - PubMed
    1. Adland E., Klenerman P., Goulder P., Matthews P. C. Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era. Frontiers in microbiology. 2015;6, article 1016 - PMC - PubMed
    1. Bolis V., Karadedos C., Chiotis I., Chaliasos N., Tsabouri S. Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge. Jornal de Pediatria. 2016;92(2):113–121. doi: 10.1016/j.jped.2015.06.007. - DOI - PubMed

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