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Review
. 2020 Oct 2;7(8):891-901.
doi: 10.1002/mdc3.13089. eCollection 2020 Nov.

Efficacy of Occupational Therapy Interventions on Quality of Life in Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis

Marco Tofani  1 , Alessandro Ranieri  2 , Giovanni Fabbrini  3   4 , Anna Berardi  3 , Elisa Pelosin  5 , Donatella Valente  3   4 , Andrea Fabbrini  4 , Matteo Costanzo  3 , Giovanni Galeoto  3
Affiliations
Review

Efficacy of Occupational Therapy Interventions on Quality of Life in Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis

Marco Tofani et al. Mov Disord Clin Pract. .

Abstract

Objective: To review studies assessing the efficacy of occupational therapy interventions on quality of life in patients with Parkinson's disease.

Method: We followed the international guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Databases (PubMed, Physiotherapy Evidence Database, OTsekeer, Scopus, Cinhal, and Web of Science) were searched to identify randomized controlled trials of occupational therapy interventions in patients with Parkinson's disease up to 2019 and with no restriction on language. The primary outcome of the meta-analysis was the evaluation of quality of life following occupational therapy interventions. Because of the heterogeneity of the studies, we examined the data by using a random effect model.

Results: We identified 15 randomized controlled trials that met the inclusion criteria, and 4 of these were included in the meta-analysis. Studies with a follow-up of 2 to 3 months showed that occupational therapy interventions significantly improved the quality of life in patients with Parkinson's disease, with a mean difference of -2.08 (95% confidence interval, -2.52 to -1.64; P < 0.00001). Studies reporting a longer follow-up (6-12 months) also showed that occupational therapy interventions improved the quality of life, with a mean difference of -2.56 (95% confidence interval, -3.52 to -1.61; P < 0.00001).

Conclusion: Different occupational therapy interventions may be effective in improving the quality of life in patients with Parkinson's disease. However, because of the limited number of studies available, the strength of the evidence should be considered moderate.

Keywords: Parkinson disease, occupational therapy, quality of life, meta‐analysis, systematic review.

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Conflict of interest statement

No specific funding was received for this work, and the authors declare that there are no conflicts of interest relevant to this work.

Figures

FIG 1
FIG 1
Flowchart of the studies included in the analysis.
FIG 2
FIG 2
Forest plot: total index of Parkinson's Disease Questionnaire 39 at 2 to 3 months of follow‐up. CI, confidence interval; SD, standard deviation.
FIG 3
FIG 3
Forest plot: total index Parkinson's Disease Questionnaire 39 at 6 to 9 months of follow‐up. CI, confidence interval; SD, standard deviation.
See this image and copyright information in PMC

References

    1. Hughes AJ, Daniel SE, Ben‐Shlomo Y, Lees AJ. The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 2002;125:861–870. - PubMed
    1. Patti F, Reggio A, Nicoletti F, Sellaroli T, Deinite G, Nicoletti F. Effects of rehabilitation therapy on Parkinsonians' disability and functional independence. J Neurol Rehabil 1996;10(4):223–231.
    1. Foster ER, Bedekar M, Tickle‐Degnen L. Systematic review of the effectiveness of occupational therapy related interventions for people with Parkinson's disease. Am J Occup Ther 2014;68(1):39–49. - PMC - PubMed
    1. Cusso ME, Donald KJ, Khoo TK. The impact of physical activity on non‐motor symptoms in Parkinson's disease: a systematic review. Front Med 2016;3:35 10.3389/fmed.2016.00035. - DOI - PMC - PubMed
    1. Radder DLM, Sturkenboom IH, van Nimwegen M, Keus SH, Bloem BR, de Vries NM. Physical therapy and occupational therapy in Parkinson's disease. Int J Neurosci 2017;127(10):930–943. - PubMed

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