Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 24;7(5):487-493.
doi: 10.14744/nci.2020.09735. eCollection 2020.

Factors affecting survival in operated pancreatic cancer: Does tumor localization have a significant effect on treatment outcomes?

Abdullah Sakin  1 , Suleyman Sahin  2 , Aysegul Sakin  3 , Muhammed Mustafa Atci  4 , Serdar Arici  4 , Nurgul Yasar  4 , Cumhur Demir  4 , Caglayan Geredeli  4 , Sener Cihan  4
Affiliations

Factors affecting survival in operated pancreatic cancer: Does tumor localization have a significant effect on treatment outcomes?

Abdullah Sakin et al. North Clin Istanb. .

Abstract

Objective: This study aims to investigate the factors affecting survival in operated pancreatic ductal adenocarcinoma (PDAC) and the possible prognostic effect of primary tumor localization on treatment outcomes.

Methods: In this study, 98 patients with curatively-operated PDAC, who were followed up and treated for the years 2008 through 2018, were enrolled. Metastatic and locally advanced stages and patients under 18 years of age were excluded from this study. Patients were divided into two groups based on the primary tumor localization as *head or *body/tail.

Results: Sixty-seven (68.3%) patients were male and 31 (31.7%) were female, with a median age of 62 years (range, 35-82 years). The numbers of patients with a primary tumor located in *head vs.*body/tail were 74 (75.4%) vs. 24 (24.6%), respectively. Patients with a primary tumor located in *head vs.*body/tail; median disease-free survival was 16.0 months vs. 13 months (p=0.972), respectively, with corresponding median overall survival was 25 months vs. 33 months (p=0.698). The level of carcinoembryonic antigen(CEA) at diagnosis (Hazard ratio[HR], 1.09 95%CI, 1.01-1.18), stage III disease (HR, 2.09 95%CI, 1.16-4.35), and receiving adjuvant treatment (HR, 0.20 95%CI, 0.09-4.34) were the independent predictors of survival.

Conclusion: Our study revealed that high levels of CEA at diagnosis and stage III disease adversely affected the survival in non-metastatic PDAC patients, while receiving adjuvant therapy had a positive effect on survival. The findings suggest that primary tumor localization did not affect survival in operated PC patients. The results on this issue are still inconsistent and under debate in the literature.

Keywords: Pancreas cancer; prognosis; survival; treatment effect; tumor localization.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
(A) DFS according to tumor localization. (B) OS according to the tumor localization. (C) DFS according to adjuvant treatment. (D) OS according to adjuvant treatment. DFS: Disease-free survival; OS: Overall survival.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Allen PJ, Kuk D, Castillo CF, Basturk O, Wolfgang CL, Cameron JL, et al. Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients With Pancreatic Adenocarcinoma. Ann Surg. 2017;265:185–91. - PMC - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics. CA Cancer J Clin. 2019;69:7–34. - PubMed
    1. Hariharan D, Saied A, Kocher HM. Analysis of mortality rates for pancreatic cancer across the world. HPB (Oxford) 2008;10:58–62. - PMC - PubMed
    1. Hidalgo M. Pancreatic cancer. N Engl J Med. 2010;362:1605–17. - PubMed
    1. Modolell I, Guarner L, Malagelada JR. Vagaries of clinical presentation of pancreatic and biliary tract cancer. Ann Oncol. 1999;10 Suppl 4:82–4. - PubMed

LinkOut - more resources