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Review
. 2020 Dec;45(6):1505-1510.
doi: 10.1111/jcpt.13244. Epub 2020 Aug 15.

Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus-associated acute respiratory distress syndrome in paediatric patients- a case series

Thao K Le  1 , Brian K Brown  2 , Katie C Namtu  2 , David M Berman  3 , Amy L Kiskaddon  2
Affiliations
Review

Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus-associated acute respiratory distress syndrome in paediatric patients- a case series

Thao K Le et al. J Clin Pharm Ther. 2020 Dec.

Abstract

What is known and objective: Reports of cidofovir dosing with extracorporeal membrane oxygenation (ECMO) support are limited. This case series describes our clinical experience and provides a literature review regarding cidofovir dosing in paediatric patients requiring ECMO support.

Case summary: Three patients with adenovirus-associated acute respiratory distress syndrome (ARDS) were treated with cidofovir while requiring ECMO support. A 27-month-old patient was treated with cidofovir 1 mg/kg/dose three times weekly, and a 19-month-old patient and an 18-year-old patient were treated with cidofovir 5 mg/kg/dose weekly.

What is new and conclusion: This case series describes the dosing and positive clinical response of cidofovir in paediatric patients with adenovirus-associated ARDS requiring ECMO support.

Keywords: acute respiratory distress syndrome; dosing regimen; paediatrics; pharmacokinetics.

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References

REFERENCES

    1. Lynch JP III, Kajon AE. Adenovirus: epidemiology, global spread of novel serotypes, and advances in treatment and prevention. Semin Respir Crit Care Med. 2016;37(4):586-602.
    1. Adenovirus Infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. 2015 Red Book: Report of the Committee on Infectious Diseases, 30th edn. Elk Grove Village, IL: American Academy of Pediatrics; 2015:226-228.
    1. Hahn J, Choi JH, Chang MJ. Pharmacokinetic changes of antibiotic, antiviral, antituberculosis and antifungal agents during extracorporeal membrane oxygenation in critically ill adult patients. J Clin Pharm Ther. 2017;42(6):661-671.
    1. Prodhan P, Bhutta A, Gossett JM, et al. Extracorporeal membrane oxygenation support among children with adenovirus infection: a review of the extracorporeal life support organization registry. ASAIO J. 2014;60(1):49-56.
    1. Lion T. Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev. 2014;27(3):441-462.

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