Phospholipid and fatty acid regulation of signal transduction at synapses: potential role for protein kinase C in information storage

Abstract

Protein kinase C has been proposed by the author to play a pivotal role in the storage of information. Its activation is directly related to synaptic potentiation as is phosphorylation of certain substrates such as protein F1. Protein F1 is found in highest concentration in those regions of temporal cortex critical for storage of information. The possibility is raised that pathology of this protein kinase C/protein F1 endogenous phosphorylation system may lead to or is responsible for the memory loss of Alzheimer's disease.