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Multicenter Study
. 2021 Jan 1;49(1):60-69.
doi: 10.1097/CCM.0000000000004717.

The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients

Diana M Verboom  1   2 , Kirsten van de Groep  1   2 , C H Edwin Boel  3 , Pieter Jan A Haas  3 , Lennie P G Derde  2 , Olaf L Cremer  2 , Marc J M Bonten  1   3
Affiliations
Multicenter Study

The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients

Diana M Verboom et al. Crit Care Med. .

Abstract

Objectives: Although the Surviving Sepsis Campaign bundle recommends obtaining blood cultures within 1 hour of sepsis recognition, adherence is suboptimal in many settings. We, therefore, implemented routine blood culture collection for all nonelective ICU admissions (regardless of infection suspicion) and evaluated its diagnostic yield.

Design: A before-after analysis.

Setting: A mixed-ICU of a tertiary care hospital in the Netherlands.

Patients: Patients acutely admitted to the ICU between January 2015 and December 2018.

Measurements and main results: Automatic orders for collecting a single set of blood cultures immediately upon ICU admission were implemented on January 1, 2017. Blood culture results and the impact of contaminated blood cultures were compared for 2015-2016 (before period) and 2017-2018 (after period). Positive blood cultures were categorized as bloodstream infection or contamination. Blood cultures were obtained in 573 of 1,775 patients (32.3%) and in 1,582 of 1,871 patients (84.5%) in the before and after periods, respectively (p < 0.0001), and bloodstream infection was diagnosed in 95 patients (5.4%) and 154 patients (8.2%) in both study periods (relative risk 1.5; 95% CI 1.2-2.0; p = 0.0006). The estimated number needed to culture for one additional patient with bloodstream infection was 17. Blood culture contamination occurred in 40 patients (2.3%) and 180 patients (9.6%) in the before period and after period, respectively (relative risk 4.3; 95% CI 3.0-6.0; p < 0.0001). Rate of vancomycin use or presumed episodes of catheter-related bloodstream infections treated with antibiotics did not differ between both study periods.

Conclusions: Implementation of routine blood cultures was associated with a 1.5-fold increase of detected bloodstream infection. The 4.3-fold increase in contaminated blood cultures was not associated with an increase in vancomycin use in the ICU.

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Conflict of interest statement

Dr. Verboom’s and Bonten’s institutions received funding from the Innovative Medicine Initiative, European Union’s Seventh Framework Programme (FP7/2007–2013), and European Federation of Pharmaceutical Industries and Associations companies’ in-kind contribution (Combatting Bacterial resistance in Europe-Carbapenem-Resistance, grant agreement 115 620). The remaining authors have disclosed that they do not have any potential conflicts of interest.

Comment in

  • Septic Until Proven Otherwise.
    Telan L, Knoefel WT. Telan L, et al. Crit Care Med. 2021 Mar 1;49(3):542-544. doi: 10.1097/CCM.0000000000004823. Crit Care Med. 2021. PMID: 33616357 No abstract available.

References

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    1. Choi EC, Chia YH, Koh YQ, et al. Appropriateness of blood culture: A comparison of practices between the emergency department and general wards. Infect Dis Health. 2019; 24:49–55
    1. Klein Klouwenberg PM, Ong DS, Bos LD, et al. Interobserver agreement of centers for disease control and prevention criteria for classifying infections in critically ill patients. Crit Care Med. 2013; 41:2373–2378

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