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. 2020 Nov 9;15(11):e0241387.
doi: 10.1371/journal.pone.0241387. eCollection 2020.

Diabetic polyneuropathy with/out neuropathic pain in Mali: A cross-sectional study in two reference diabetes treatment centers in Bamako (Mali), Western Africa

Youssoufa Maiga  1   2   3 , Salimata Diallo  2 , Fatoumata Dite Nènè Konipo  1 , Oumar Sangho  1 , Modibo Sangaré  1 , Seybou H Diallo  1   2 , Saliou Mahamadou  4 , Yann Péréon  5 , Bernard Giumelli  6 , Awa Coulibaly  2 , Mariam Daou  2 , Zoumana Traoré  7 , Djeneba Sow Sylla  1   8 , Mohamed Albakaye  2 , Cheick Oumar Guinto  1 , Madani Ouologem  6 , Adama S Sissoko  1 , Hamar A Traoré  1 , Souleymane Papa Coulibaly  1 , Philippe Damier  9 , Nadine Attal  10 , Julien Nizard  3   9   11
Affiliations

Diabetic polyneuropathy with/out neuropathic pain in Mali: A cross-sectional study in two reference diabetes treatment centers in Bamako (Mali), Western Africa

Youssoufa Maiga et al. PLoS One. .

Abstract

Introduction: Diabetic polyneuropathy (DPN) with or without neuropathic pain is a frequent complication of diabetes. This work aimed to determine the prevalence of diabetic polyneuropathy, to describe its epidemiological aspects, and to analyze the therapeutic itinerary of patients with DPN.

Methods: This was a cross-sectional, descriptive study performed synchronously over six months at two major follow-up sites for patients with diabetes in Mali. DPN was diagnosed based on the Michigan Neuropathy Screening Instrument (MNSI). The neuropathic nature of the pain and the quality of life of patients were evaluated by the DN4 and the ED-5D scale, respectively. We used three (3) different questionnaires to collect data from patients (one at inclusion and another during the follow-up consultation) and from the caregivers of patients with DPN.

Results: We included 252 patients with diabetes, and DPN was found to have a healthcare facility-based prevalence of 69.8% (176/252). The sex ratio was approximately three females for every male patient. The patients were mostly 31 to 60 years of age, 83% had type 2 diabetes, and 86.9% had neuropathic pain Approximately half of the patients (48.3%) had autonomic neuropathy and they reported moderate to intense pain, which was mainly described as a burning sensation. The patients exhibited impaired exteroceptive and proprioceptive sensations in 51.7% of cases. The patients smoked tobacco in 3.4% of cases, while 36.6% of the patients were obese and had dyslipidemia. The caregivers clearly indicated that appropriate medications were not readily accessible or available for their patients with DPN.

Conclusion: The healthcare facility-based prevalence of DPN with or without neuropathic pain was high in our cohort. These inexpensive and easy-to-use tools (MNSI, DN4) can be used to adequately diagnose DPN in the African context. In Mali, screening and early treatment of patients at risk of DPN should allow for a reduction of the burden of the disease, while caregivers need to be adequately trained to manage DPN.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Treatment status of patients in relation to neuropathic pain.
Fig 2
Fig 2. Patients recourse.
Fig 3
Fig 3. Gris-gris from marabouts attached to the lower limbs of an adult male patient with DPN.
Fig 4
Fig 4. Scarification of the lower limb in a patient with DPN.
See this image and copyright information in PMC

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