Insight into anti-oxidative carbohydrate polymers from medicinal plants: Structure-activity relationships, mechanism of actions and interactions with bovine serum albumin

Abstract

Recently, research associated with natural anti-oxidants leads to the chemical characterization of many compounds possessing strong anti-oxidant activity. Among these anti-oxidants, naturally occurring carbohydrate polymers containing pectic arabinogalactans esterified with phenolic acids in monomeric and dimeric forms are noteworthy. The presence of highly branched arabinogalactan type II side chains and sugar linked phenolic acid residues have been resolved as important parameters. The anti-oxidant activity of these compounds depend on their ability to convert free radicals into stable by-products and themselves oxidized to more stable and less reactive resonance stabilized radicals. Moreover, these carbohydrate polymers form water soluble stable complexes with protein. Such findings support their applications in a diversity of fields including food industry and pharmacy. This review highlights experimental evidences supporting that the carbohydrate polymers containing phenolic polysaccharides may become promising drug candidate for the prevention of aging and age related diseases.

Keywords: Anti-oxidant activity; Interactions with BSA; Structure–activity relationships.