Roles of exosomal miRNA in vascular aging

Abstract

Aging is a major risk factor for human diseases. As global average life expectancy has lengthened, delaying or reducing aging and age-related diseases has become an urgent issue for improving the quality of life. The vascular aging process represents an important link between aging and age-related diseases. Exosomes are small extracellular vesicles (EV) that can be secreted by almost all eukaryotic cells, and they deliver characteristic biological information about donor cells to regulate the cellular microenvironment, mediate signal transmission between neighboring or distant cells, and affect the expression of target genes in recipient cells. Many recent studies have shown that exosomal microribonucleic acids (miRNA) are involved in the regulation of vascular aging by participating in the physiological functions of vascular cells and the destruction and remodeling of the extracellular matrix (ECM). This review summarizes the regulatory functions of exosomal miRNA in vascular aging because they interact with the ECM, and participate in vascular cell senescence, and the regulation of senescence-related functions such as proliferation, migration, apoptosis, inflammation, and differentiation.

Keywords: Angiotensin II (PubChem CID:172198); Calcium phosphate (PubChem CID: 24456); Cobalt chloride (PubChem CID: 24288); Exosomes; HSP (PubChem CID: 127339120) TNF-alpha (PubChem CID: 317231557); Iron citrate (PubChem CID: 4989393); Nicotine (PubChem CID:89594); Nitric oxide (PubChem CID: 145068); Reactive oxygen species (PubChem CID: 135292933); TGF-beta (PubChem CID: 56842206); Vascular aging; miRNA.