. 2020 Nov 9;12(1):95.

doi: 10.1186/s13073-020-00792-9.

Genomics in the era of COVID-19: ethical implications for clinical practice and public health

Gail Geller^{1

2

3}, Priya Duggal⁴, Chloe L Thio^{5

6}, Debra Mathews^{7

5}, Jeffrey P Kahn^{7

4}, Lisa L Maragakis^{5

8}, Brian T Garibaldi^{5

9}

Affiliations

¹ Berman Institute of Bioethics, Johns Hopkins University, Deering Hall, Room 202, 1809 Ashland Ave., Baltimore, MD, 21205, USA. ggeller@jhu.edu.
² Johns Hopkins University School of Medicine, Baltimore, MD, USA. ggeller@jhu.edu.
³ Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA. ggeller@jhu.edu.
⁴ Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA.
⁵ Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁶ Johns Hopkins School of Medicine Hepatitis Center, 855 N. Wolfe St. Rangos Room 533, Baltimore, MD, 21205, USA.
⁷ Berman Institute of Bioethics, Johns Hopkins University, Deering Hall, Room 202, 1809 Ashland Ave., Baltimore, MD, 21205, USA.
⁸ Johns Hopkins School of Medicine Infection Control, 600 N. Wolfe St., Osler 425, Baltimore, MD, 21205, USA.
⁹ Johns Hopkins University School of Medicine Pulmonology, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA.

PMID: 33168072
PMCID: PMC7649891
DOI: 10.1186/s13073-020-00792-9

Genomics in the era of COVID-19: ethical implications for clinical practice and public health

Gail Geller et al. Genome Med. 2020.

. 2020 Nov 9;12(1):95.

doi: 10.1186/s13073-020-00792-9.

Authors

Gail Geller^{1

2

3}, Priya Duggal⁴, Chloe L Thio^{5

6}, Debra Mathews^{7

5}, Jeffrey P Kahn^{7

4}, Lisa L Maragakis^{5

8}, Brian T Garibaldi^{5

9}

Affiliations

¹ Berman Institute of Bioethics, Johns Hopkins University, Deering Hall, Room 202, 1809 Ashland Ave., Baltimore, MD, 21205, USA. ggeller@jhu.edu.
² Johns Hopkins University School of Medicine, Baltimore, MD, USA. ggeller@jhu.edu.
³ Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA. ggeller@jhu.edu.
⁴ Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA.
⁵ Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁶ Johns Hopkins School of Medicine Hepatitis Center, 855 N. Wolfe St. Rangos Room 533, Baltimore, MD, 21205, USA.
⁷ Berman Institute of Bioethics, Johns Hopkins University, Deering Hall, Room 202, 1809 Ashland Ave., Baltimore, MD, 21205, USA.
⁸ Johns Hopkins School of Medicine Infection Control, 600 N. Wolfe St., Osler 425, Baltimore, MD, 21205, USA.
⁹ Johns Hopkins University School of Medicine Pulmonology, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA.

PMID: 33168072
PMCID: PMC7649891
DOI: 10.1186/s13073-020-00792-9

Abstract

Genomic studies of patients with COVID-19, or exposed to it, are underway to delineate host factors associated with variability in susceptibility, infectivity, and disease severity. Here, we highlight the ethical implications-both potential benefits and harms-of genomics for clinical practice and public health in the era of COVID-19.

Keywords: COVID-19; Ethics; Host genomics.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

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Genomics in Patient Care and Workforce Decisions in High-Level Isolation Units: A Survey of Healthcare Workers.
Gerber JE, Geller G, Boyce A, Maragakis LL, Garibaldi BT. Gerber JE, et al. Health Secur. 2021 May-Jun;19(3):318-326. doi: 10.1089/hs.2020.0182. Epub 2021 Apr 6. Health Secur. 2021. PMID: 33826422 Free PMC article.
Ethical Issues in Genetics and Infectious Diseases Research: An Interdisciplinary Expert Review.
Walker A, Bonham VL, Boyce A, Clayton EW, Garcia D, Johnson S, Laeyendecker O, Lewis M, Margolick JB, Mathews D, Parker MJ, Spicer P, Thio CL, Geller G, Kahn J. Walker A, et al. Ethics Med Public Health. 2021 Sep;18:100684. doi: 10.1016/j.jemep.2021.100684. Epub 2021 Jun 7. Ethics Med Public Health. 2021. PMID: 34263019 Free PMC article.
Ethically utilising COVID-19 host-genomic data.
Gyngell C, Christodoulou J, Savulescu J. Gyngell C, et al. NPJ Genom Med. 2021 May 10;6(1):31. doi: 10.1038/s41525-021-00194-9. NPJ Genom Med. 2021. PMID: 33972547 Free PMC article.
The Impact of Transmissible Microbes: How the Cystic Fibrosis Community Mobilized Against Cepacia.
Mueller R. Mueller R. Perspect Biol Med. 2023;66(1):89-106. doi: 10.1353/pbm.2023.0005. Perspect Biol Med. 2023. PMID: 38662010 Free PMC article.
Biomedical Research COVID-19 Impact Assessment: Lessons Learned and Compelling Needs.
Cook NL, Lauer MS. Cook NL, et al. NAM Perspect. 2021 Jul 26;2021:10.31478/202107e. doi: 10.31478/202107e. eCollection 2021. NAM Perspect. 2021. PMID: 34611607 Free PMC article. Review. No abstract available.

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References

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Genomics in the era of COVID-19: ethical implications for clinical practice and public health

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Genomics in the era of COVID-19: ethical implications for clinical practice and public health

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