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Review
. 2021 Jan 15:210:112983.
doi: 10.1016/j.ejmech.2020.112983. Epub 2020 Oct 31.

Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis

Sara Consalvi  1 , Giovanna Poce  1 , Carla Ghelardini  2 , Lorenzo Di Cesare Mannelli  2 , Paola Patrignani  3 , Annalisa Bruno  3 , Maurizio Anzini  4 , Vincenzo Calderone  5 , Alma Martelli  5 , Lara Testai  5 , Antonio Giordani  6 , Mariangela Biava  7
Affiliations
Review

Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis

Sara Consalvi et al. Eur J Med Chem. .

Abstract

This review discusses the rational for further studies of COX-2 inhibitors-NO releaser hybrids (NO-Coxibs) in the pharmacological treatment of the airway inflammation in Cystic Fibrosis (CF). Our research group developed several classes of NO-Coxibs for the pharmacological treatment of arthritis, and among them several compounds showed an outstanding in vivo efficacy and good pharmacokinetic properties. The good antiinflammatory properties displayed by these compounds during the previous screening could, by itself, suggest appropriate candidates for further testing in CF.

Keywords: CINODs; COX-2; Cystic fibrosis; Inflammation.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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