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Comment
. 2020 Dec;21(12):1480-1482.
doi: 10.1038/s41590-020-00820-1.

CRELD1 controls T cell homeostasis

Fotini Gounari  1
Affiliations
Comment

CRELD1 controls T cell homeostasis

Fotini Gounari. Nat Immunol. 2020 Dec.
No abstract available

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Figures

Fig 1
Fig 1
Comparing the 10% of healthy individuals with the lowest CRELD1 expression to the 10% with the highest CRELD1 expression suggested a role for CRELD1 in regulating an expression signature associated with immunological aging and maintaining T cell homeostasis. Conditional T cell specific Creld1 ablation in mice established this finding and further indicated that Creld1 in T cells promotes NFAT and Wnt signaling.
See this image and copyright information in PMC

Comment on

  • CRELD1 modulates homeostasis of the immune system in mice and humans.
    Bonaguro L, Köhne M, Schmidleithner L, Schulte-Schrepping J, Warnat-Herresthal S, Horne A, Kern P, Günther P, Ter Horst R, Jaeger M, Rahmouni S, Georges M, Falk CS, Li Y, Mass E, Beyer M, Joosten LAB, Netea MG, Ulas T, Schultze JL, Aschenbrenner AC. Bonaguro L, et al. Nat Immunol. 2020 Dec;21(12):1517-1527. doi: 10.1038/s41590-020-00811-2. Epub 2020 Nov 9. Nat Immunol. 2020. PMID: 33169013

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