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Review
. 2020 Nov 9;91(13-S):e2020014.
doi: 10.23750/abm.v91i13-S.10683.

Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases

Aysha Karim Kiani  1 , Benedetto Falsini  2 , Lucia Ziccardi  3 , Elena Gusson  4 , Domenica Mangialavori  5 , Francesca Allegrini  6 , Emma Colao  7 , Matteo Bertelli  8
Affiliations
Review

Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases

Aysha Karim Kiani et al. Acta Biomed. .

Abstract

Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-inflammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

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