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Meta-Analysis
. 2021 Sep;33(9):2369-2377.
doi: 10.1007/s40520-020-01745-3. Epub 2020 Nov 10.

Taste receptor polymorphisms and longevity: a systematic review and meta-analysis

Danilo Di Bona #  1 , Alberto Malovini #  2 , Giulia Accardi  3 , Anna Aiello  3 , Giuseppina Candore  3 , Anna Ferrario  4 , Mattia E Ligotti  3 , Anna Maciag  4 , Annibale A Puca  4   5 , Calogero Caruso  6
Affiliations
Meta-Analysis

Taste receptor polymorphisms and longevity: a systematic review and meta-analysis

Danilo Di Bona et al. Aging Clin Exp Res. 2021 Sep.

Abstract

Bitter taste receptors (TAS2R) are involved in a variety of non-tasting physiological processes, including immune-inflammatory ones. Therefore, their genetic variations might influence various traits. In particular, in different populations of South Italy (Calabria, Cilento, and Sardinia), polymorphisms of TAS2R16 and TAS238 have been analysed in association with longevity with inconsistent results. A meta-analytic approach to quantitatively synthesize the possible effect of the previous variants and, possibly, to reconcile the inconsistencies has been used in the present paper. TAS2R38 variants in the Cilento population were also analysed for their possible association with longevity and the obtained data have been included in the relative meta-analysis. In population from Cilento no association was found between TAS2R38 and longevity, and no association was observed as well, performing the meta-analysis with data of the other studies. Concerning TAS2R16 gene, instead, the genotype associated with longevity in the Calabria population maintained its significance in the meta-analysis with data from Cilento population, that, alone, were not significant in the previously published study. In conclusion, our results suggest that TAS2R16 genotype variant is associated with longevity in South Italy.

Keywords: Immune-inflammatory responses; Longevity; Meta-analysis; Taste receptors.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Meta-analysis of the two case–control studies (three for C) of the TAS2R38 polymorphism and longevity using the random effects model. The OR and 95% CI for the effect of the various genotypes/haplotypes on longevity are plotted on the graphs. Cilento refers to data presented in Table 1a, b. a AVI/AVI + PAV/AVI vs. PAV/PAV, b AVI/AVI vs. PAV/PAV, c AVI vs. PAV
Fig. 2
Fig. 2
Meta-analysis of the two case–control studies of the TAS2R16 polymorphism and longevity using the random effects model. The OR and 95% CI for the effect of the various genotypes/alleles on longevity are plotted on the graphs. a CC + CT vs. TT; b CC vs. TT; c C vs. T
See this image and copyright information in PMC

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