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Meta-Analysis
. 2020 Nov 10;15(11):e0241811.
doi: 10.1371/journal.pone.0241811. eCollection 2020.

Adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia: Systematic review and meta-analysis

Demeke Mesfin Belay  1 , Wubet Alebachew Bayih  1 , Abebaw Yeshambel Alemu  1 , Aklilu Endalamaw Sinshaw  2 , Demewoz Kefale Mekonen  1 , Amare Simegn Ayele  3 , Wasihun Hailemichael Belayneh  4 , Henoke Andualem Tegared  4 , Biniam Minuye Birihane  1
Affiliations
Meta-Analysis

Adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia: Systematic review and meta-analysis

Demeke Mesfin Belay et al. PLoS One. .

Erratum in

Abstract

Background: The magnitude of adverse birth outcome among diabetic pregnant women is high in low-and-middle income countries, like Ethiopia. Precise epidemiological evidence is necessary to plan, evaluate and improve effective preventive measures. This systematic review and meta-analysis is the first to estimate the pooled prevalence of adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia.

Methods: PubMed, Cochrane Library, Google Scholar, SCOPUS, Web of Science and PsycINFO, and article found in University online repository were accessed. Observational studies such as cross-sectional, case-control and prospective cohort reported using English language was involved. I2 statistic was used to check heterogeneity. Egger's test and funnel plot were used to measure publication bias. Weighted inverse variance random effects model was also performed.

Results: Seven studies with 1,225 study participants were retrieved to estimate the pooled prevalence of adverse birth outcome and associated factors. The pooled prevalence of adverse birth outcome among diabetic pregnant women was 5.3% [95% CI; 1.61, 17.41]. Fasting blood glucose level above 100 mg/dl [Adjusted Odds ratio (AOR) = 10.51; 95% Confidence Interval (CI) = 5.90, 15.12], two hour post prandial glucose level above 120 mg/dl [AOR = 8.77; 95% CI = 4.51, 13.03], gestational age <37 completed week [AOR = 9.76; 95% CI = 5.29, 14.23], no ANC follow-up [AOR = 10.78; 95% CI = 6.12, 15.44], history of previous adverse outcomes [AOR = 3.47; 95% CI = 1.04, 5.90], maternal age < 30 years [AOR = 3.47; 95% CI = 1.04, 5.90], and illiteracy [AOR = 2.89; 95% CI = 0.81,4.97)] were associated factors of adverse birth outcome.

Conclusions: The pooled prevalence of adverse birth outcomes among diabetic pregnant women in Ethiopia was high. Child born from mothers who were illiterate, maternal age < 30 years, gestational age < 37 completed weeks, history of previous adverse birth outcomes and no ANC follow-up increased the risk of adverse birth outcome.

Trial registration: It is registered in PROSPERO data base: (PROSPERO 2020: CRD42020167734).

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of study selection for systematic review and meta- analysis of adverse birth outcomes and its associated factors among diabetic women in Ethiopia, 2020.
Fig 2
Fig 2. Forest plot of overall prevalence of adverse birth outcomes among diabetic women in Ethiopia, 2020.
Fig 3
Fig 3. Funnel plot to show publication bias.
Fig 4
Fig 4. Sensitivity analysis of adverse birth outcomes among diabetics mother in Ethiopia, 2020.
See this image and copyright information in PMC

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